Project Grant R01AR084253
- This Project Grant award from the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $115,000.00 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to investigate the potential role of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) in improving cardiovascular and kidney outcomes for patients with Systemic Lupus Erythematosus (SLE) and Lupus Nephritis. The...
- This Project Grant award for $300,000 from the Department of Health and Human Services' National Institutes of Health (CFDA 93.310 Trans-NIH Research Support) to Brigham & Women's Hospital Inc. (a subsidiary of Partners Healthcare System) supports research on the role of activated neutrophils and T cells in the pathogenesis of systemic lupus erythematosus (SLE), lupus nephritis, and vasculitis. The research aims to investigate how immune cell abnormalities, specifically the generation of...
- This $793,093 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to define the regulatory landscape of systemic lupus erythematosus (SLE) and its cardiovascular disease (CVD) comorbidity. The grantee, Oklahoma Medical Research Foundation, will conduct systematic, high-throughput studies in macrophages derived from induced pluripotent stem cells to identify genetic variants that disrupt regulatory...
- The federal Project Grant award of $300,000 was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to Temple University in Philadelphia, PA. The funding supports research focused on understanding the role of the kallikrein-kinin system and its ability to suppress the type I interferon response, which is a hallmark of systemic lupus erythematosus (SLE). The research aims to explore new pathways for interferon suppression and their...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research to characterize hematopoietic stem cell (HSC) impairment in a mouse model of systemic lupus erythematosus (SLE)-like disease. The $216,113 award to New York University School of Medicine will be used to test the hypothesis that SLE-like disease impairs HSC activity, potentially...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $704,424 to support research efforts to identify rare pathogenic variants and their functional consequences in Systemic Lupus Erythematosus (SLE). The key objectives are to: 1) apply whole genome sequencing on 127 SLE multiplex, simplex, and early-onset pediatric cases to define...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $715,957.00 to Northwestern University to conduct research on the mechanisms by which type I interferon cytokines support the production and expansion of T peripheral helper (Tph) cells in systemic lupus erythematosus (SLE) patients. The research aims to elucidate the molecular pathways...
- This $544,689 federal Project Grant was awarded on August 6, 2025 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports research at the University of Florida to investigate the diagnosis and treatment of diffuse alveolar hemorrhage (DAH), a severe lung complication that can occur in patients with systemic lupus erythematosus. The research aims to understand the...
- This federal Project Grant award for $3,364,935.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) through the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to functionally and mechanistically characterize genetic factors that contribute to the development of systemic lupus erythematosus (SLE). The research aims to elucidate the role of autophagy, a cellular process, in the pathogenesis of SLE, particularly in immune cells and...
- This federal Project Grant award in the amount of $700,000.00, provided by the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training program), supports research to investigate the role of the ARID3A protein in systemic lupus erythematosus (SLE) and other autoimmune diseases. The award will fund a research project at the University of Oklahoma Health Sciences Center to: 1) define genes and epigenetic regions directly regulated by ARID3A expression...
This federal Project Grant award, issued by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), supports research on pregnancy and cardiovascular health outcomes for women with systemic lupus erythematosus (lupus). The $372,210 award, with a project period from September 2025 to August 2029, will fund investigations into the use of hydroxychloroquine and other lupus medications during pregnancy, and the relationships between hypertensive disorders of pregnancy and long-term cardiovascular disease risk for this population. The research aims to improve medical management of lupus during pregnancy and identify strategies to prevent preeclampsia and other hypertensive complications. This project is funded under the Arthritis, Musculoskeletal and Skin Diseases Research grant program (CFDA 93.846).
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $372.2k | 9/11/25 |