The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $522,714 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Rensselaer Polytechnic Institute (RPI) in Troy, NY, effective January 1, 2025 through December 31, 2029. The grant supports research to investigate the role of stretch activation (SA) in maintaining skeletal muscle endurance, and to determine the underlying kinetic and structural mechanisms that differentiate SA characteristics across different muscle fiber types. The research aims to expand understanding of SA's importance in mammalian skeletal muscle function and its potential contribution to diseases involving impaired muscle function, such as hypertrophic cardiomyopathy and distal arthrogryposis. The project combines studies using both mammalian and Drosophila models to comprehensively explore these new mechanisms and their translational implications.
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