Project Grant R01AR083628

Award Date 8/5/24
Completion Date 7/31/28
Dollars Obligated $178K
Federal Grant Program
93.846
Assistance Type
Project Grant
Place of Performance
San Francisco, CA 94143, USA
Similar Awards
The National Center for Advancing Translational Sciences (NCATS) awarded a $407,792 Project Grant (CFDA 93.350) to Nostopharma LLC, a woman-owned small disadvantaged business, to develop a novel localized treatment for Fibrodysplasia Ossificans Progressiva (FOP), an ultrarare genetic disease. The project aims to create extended-release formulations of Hedgehog pathway inhibitors, such as arsenic trioxide, encapsulated in immunomodulatory nanoparticles for intramuscular administration. The goal...
This $408,031 Project Grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports a comparative effectiveness study of current treatments for children with chronic nonbacterial osteomyelitis (CNO). The study aims to determine the impact of prolonged non-steroidal anti-inflammatory drug (NSAID) treatment on reducing disease flares, as well as compare the...
This federal Project Grant award, totaling $317,476.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award will support research at the University of Alabama at Birmingham (UAB) to investigate the molecular genetic causes of gout flares. The project aims to conduct differential gene expression analysis of myeloid cell subsets in peripheral blood and...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $342,975 to Mayo Clinic from July 2025 to May 2030 to conduct research on preventing and treating arthrofibrosis, a debilitating joint condition that can occur after total knee replacement surgery. The key objectives of this award are to (1) assess whether local sustained release of the...
The federal Project Grant award R01AR085642, totaling $628,174.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award is supporting research at the University of Southern California (USC) to investigate the cellular origins and molecular mechanisms underlying arthrofibrosis, a debilitating fibrotic joint disorder. The project aims to elucidate the role...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $196,460 to the University of Pittsburgh to test a novel microphysiological system as a tool to study neuroimmune interactions in osteoarthritis pain. The goal is to use this system, which includes cartilage, synovial-like, and innervated tissue, to investigate the influence...
This $168,438 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA Program 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research, will support a research project to characterize the phenotypic and neurophysiological features of cognitive dysfunction in individuals with fibromyalgia. The key objectives are to: 1) Compare subjective and objective cognitive assessments between individuals with fibromyalgia and healthy...
This Project Grant award for $144,362 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate the critical factors regulating the fate determination of chondrocyte progenitor cells during synovial joint and bone development. The objectives of the study are to determine: 1) the extent to which candidate transcription factors like PITX1 and ATF4...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) provides $219,605 to the Regents of the University of Michigan to conduct research on the role of the PIEZO1 ion channel in the development of post-traumatic osteoarthritis (PTOA). The research aims to 1) characterize the bi-directional regulation between PIEZO1 mechanotransduction and canonical Wnt/β-catenin signaling in...
This Project Grant award of $1,150,474 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research to explore the cellular and molecular mechanisms driving large-scale bone regeneration. The research aims to unravel the intricate events necessary for extensive bone repair by investigating the role of a sentinel-type cell population marked by SOX9 expression in...

This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under CFDA program 93.846 "Arthritis, Musculoskeletal and Skin Diseases Research", provides $177,650 to conduct an observational study on the use of anti-IL1 therapy to reduce flare activity and heterotopic ossification in patients with Fibrodysplasia Ossificans Progressiva (FOP), a rare disease causing progressive and irreversible loss of mobility.

The key objectives are to: 1) Determine if FOP patients have decreased flare activity while on anti-IL1 therapy, 2) Quantify new heterotopic ossification formation in FOP patients treated with anti-IL1 therapy, and 3) Explore if inflammatory cytokine measurements can be used as biomarkers to monitor flare activity and inflammation in FOP patients on anti-IL1 therapy. The observational study will enroll 11 FOP patients aged 6-18 years over 4 years, with assessments including flare diaries, pain scales, low-dose whole-body CT imaging, bloodwork, and patient-reported outcomes. The findings aim to address critical knowledge gaps and generate tools to support future interventional studies on FOP treatment.

Generated 7/1/25, 4:10 AM