This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research Federal Grant Program (CFDA 93.846), will enable Duke University to develop a 3D skin model system to investigate interactions between the skin microbiome and skin cell populations. The $198,782 award, effective April 10, 2025 through March 31, 2027, will fund the creation of 3D reconstructed human epidermis (RHE)...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to elucidate the underlying molecular mechanisms of cellular mechanosensitivity. The $387,662 award to Duke University will enable the development of novel biosensors and techniques to investigate how mechanical forces and protein phosphorylation regulate the mechanical state and force transmission capabilities of key linker...
The Regents of the University of Minnesota was awarded a $354,222 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant will support research to investigate how the dystrophin-associated protein complex (DAPC) senses and adapts to biochemical, mechanical, and topographic cues in the cell microenvironment, and how this regulates myotube orientation and...
This federal Project Grant award, valued at $230,212 and provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), supports research under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The goal of the research is to investigate how the immune system, specifically dendritic epidermal T cells (DETCs), drives functional heterogeneity in skin epithelial stem cells within and across different niches. The research will shed...
This Project Grant award, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to define the role and regulation of the keratin protein Keratin 9 (KRT9/K9) in the adaptation of skin keratinocytes to mechanical stress. The $208,160 award will fund a research project to investigate how KRT9/K9 expression and the Hippo signaling pathway are involved in...
The National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded New York University School of Medicine $409,311.92 under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) from April 5, 2021 to January 25, 2022. The project grant funding supports research into the role of T follicular helper (TFH) cells in the pathogenesis of dermatomyositis, a severe inflammatory myopathy. Specifically, the award will fund studies to...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $439,791.00 over a 5-year period from March 1, 2025 to February 28, 2030 to The University of Texas Southwestern Medical Center. The funding will support research to investigate the molecular mechanisms underlying myoblast fusion, which is essential for skeletal muscle development and...
This Project Grant award of $257,310 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research at the University of Illinois investigating the role of extracellular vesicles in mediating communication between endothelial cells and fibroblasts during skin wound healing. The research plan utilizes in vitro and in vivo models to examine how endothelial...
This Project Grant award of $1,222,648.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The award will fund research by Cornell University over a 5-year period starting on Sep 1, 2024 to identify the mechanism responsible for "ultra-rapid" induction of mechanoresponsive genes and determine the functional consequences of impaired...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund research to develop improved gene replacement and editing therapies for Duchenne muscular dystrophy (DMD). The total award amount is $671,240 and the project period runs from January 22, 2025 to December 31, 2029. The key research objectives are to: 1) Refine technologies for expressing...