This Project Grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) aims to identify structural traits that predict fracture risk in older men and women, independent of areal bone mineral density (aBMD). The $1,804,329 award, with a start date of April 15, 2024 and an ultimate completion date of January 31, 2029, will leverage high-resolution imaging and mechanical testing of cadaveric femurs to determine how structural trait patterns associated with low femur strength vary based on external femur size. The research will also use longitudinal DXA data to test the hypothesis that strength-decline trajectories differ among baseline femoral neck area tertiles, and that these trajectories are linked to fracture risk within those subgroups. The project includes sub-awards to the California Pacific Medical Center Research Institute to provide statistical analysis and interpretation, and to the University of Colorado and Oregon Health & Science University to develop computational models and provide expertise in bone biology and epidemiology.
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