Project Grant R01AI201713
- The National Institute of Allergy and Infectious Diseases awarded Vanderbilt University Medical Center $224,080 on August 3, 2026, for research into cytokine cargo signaling from extracellular vesicles under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds exploratory research on how extracellular vesicles transport cytokines to mediate immune signaling in inflammation. The work addresses a knowledge gap in understanding how cytokines carried on or within...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Vanderbilt University Medical Center a Project Grant of $751,138 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 16, 2025, with completion targeted for June 30, 2030. This award supports basic immunological research investigating the role of glutaminase-dependent metabolism in dendritic cells and its contribution to inflammatory diseases and immune...
- The National Institute of Allergy and Infectious Diseases awarded Vanderbilt University Medical Center $262,388 on August 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how the RNA binding protein HNRNPA2B1 regulates macrophage responses to Mycobacterium tuberculosis infection. The research examines alternative splicing as a mechanism controlling the balance between MTB virulence and host antimicrobial defenses. The award funds work to define how...
- The National Institute of Allergy and Infectious Diseases awarded University of Tennessee Health Science Center $468,368 on May 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate LGR4 expression and its role in HIV-associated atherosclerosis. The research examines molecular mechanisms linking controlled HIV infection to macrophage activation and accelerated atherosclerosis in people living with HIV on antiretroviral therapy. Using an experimental...
- The National Institute of Allergy and Infectious Diseases awarded Vanderbilt University $152,600 on November 29, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) for research on targeted delivery of STING agonists to regulatory T cells for cancer immunotherapy. The project, designated F32AI200412, focuses on engineering a bispecific nanobody-STING agonist conjugate designed to selectively reprogram regulatory T cells to enhance anti-tumor immunity while minimizing...
- The National Institute of Allergy and Infectious Diseases awarded Vanderbilt University $105,216 on December 23, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of lipid-laden macrophages in Staphylococcus aureus osteomyelitis abscess formation. The research employs multimodal imaging techniques, including matrix-assisted laser desorption/ionization imaging mass spectrometry, to examine the spatial localization and physiology of...
- The National Institute of Allergy and Infectious Diseases awarded Vanderbilt University $448,089 on February 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and test engineered extracellular vesicles (EVs) as a tolerogenic immunotherapy platform for autoimmune disease. The funded work focuses on engineering EVs derived from mesenchymal stem cells to deliver autoantigens in a tolerogenic context, with initial testing in a multiple sclerosis model....
- The National Institute of Allergy and Infectious Diseases awarded Vanderbilt University Medical Center $153,560 on October 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate subcellular compartmentalization of sulfur metabolism in Acinetobacter baumannii, a bacterial pathogen responsible for 15–25 percent of ventilator-associated pneumonia cases in hospitals. The research examines how A. baumannii regulates sulfur uptake and metabolism during...
- The National Institute of Allergy and Infectious Diseases awarded Vanderbilt University Medical Center $262,500 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and validate technology for mapping T cell recognition of Mycobacterium tuberculosis peptides. The award funds development of TCR-MAP, a technology enabling unbiased identification of antigen recognition by CD4 T cells in tuberculosis infection. The project will develop a...
- The National Institute of Allergy and Infectious Diseases awarded Cincinnati Children's Hospital Medical Center $202,500 on June 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant R21AI200165). The award funds basic research examining how peroxisomes and peroxisomal fatty acid β-oxidation regulate CD4+ T cell inflammatory responses and shape disease pathogenesis in inflammatory and autoimmune conditions. The research investigates the role of...
The National Institute of Allergy and Infectious Diseases awarded Vanderbilt University Medical Center $622,476 on August 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate metabolic mechanisms of regulatory T cell dysfunction in atherosclerosis. The research examines how oxidized phospholipids accumulate in atherosclerotic plaques and impair the protective function of T regulatory cells (Tregs) that normally suppress chronic arterial inflammation. The project focuses on the molecular pathways through which oxidized phospholipid OXPAPC promotes a pro-inflammatory phenotype in Tregs, reducing their ability to prevent atherosclerosis progression. Preliminary data indicate that CD36 and AKT-mediated activation of ATP-citrate lyase (ACLY) mediate these effects; ACLY-deficient T cells show resistance to OXPAPC-induced modifications when differentiated to Tregs. The work will test ACLY as a potential therapeutic target to restore Treg function and protect against atherosclerosis. Work is performed at Vanderbilt University Medical Center in Forest Hills, Tennessee, with a period of performance through July 31, 2031. This is a Project Grant, the standard assistance type for investigator-initiated research under the NIAID program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $622.5k | 8/3/26 |