Project Grant R01AI201175
- The National Institute of Allergy and Infectious Diseases awarded Albany Medical College $604,681 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the molecular and epigenetic mechanisms of endothelial inflammatory memory in sepsis survivors vulnerable to secondary infections, particularly pneumonia. The recipient will examine how transcription factors STAT3 and JUNB, and the histone methyltransferase EZH2, establish and maintain...
- The National Institute of Allergy and Infectious Diseases (NIAID), a component of the Department of Health and Human Services National Institutes of Health, awarded $246,000 to Albany Medical College on May 1, 2026, for a Project Grant (R21AI198413) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research to investigate the role of human Fc gamma receptor I (hFcγRI) in cross-presentation and CD8 T-cell responses in the respiratory mucosa. The project...
- The National Institute of Allergy and Infectious Diseases awarded the University of Louisville $630,173 on May 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how Yersinia pestis modulates host extracellular vesicles and evades immune response in pneumonic plague. The research defines changes in pulmonary extracellular vesicle populations and inflammatory potential during pneumonic plague infection, and uses Y. pestis mutants to delineate the...
- The National Institute of Allergy and Infectious Diseases awarded Albany Medical College $451,000 on February 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of Wnt/β-catenin signaling in alveolar epithelial repair during tuberculosis infection. The research addresses how chronic type I interferon signaling suppresses Wnt/β-catenin activity and impairs lung regeneration in tuberculosis-susceptible mice. The project encompasses three aims:...
- The National Institute of Allergy and Infectious Diseases awarded East Carolina University $223,957 on September 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to evaluate how bactericidal permeability-increasing protein-induced protein A (BIPA) contributes to Yersinia pestis pathogenesis during pneumonic plague. The research will define BIPA's function in early events of pneumonic plague and identify proteins regulated by BIPA that contribute to...
- The National Institute of Allergy and Infectious Diseases awarded East Carolina University $226,500 on February 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research characterizing how zinc depletion and host calprotectin balance impact pulmonary inflammation during pneumonic plague infection. The research investigates the role of Yersinia pestis YbtX, an inner membrane protein and zinc transporter, in driving the hyper-inflammatory response that...
- Federal Grant Award Summary Albany Medical College received a $164,000 Project Grant award from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective June 6, 2025, with completion targeted for May 31, 2027. The project, "Development of Conformer-Specific Anti-I-A Class II Monoclonal Antibodies," focuses on identifying and characterizing novel monoclonal antibodies (MAbs) that selectively recognize...
- The National Institute of Allergy and Infectious Diseases awarded New York University $827,768 on August 13, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how microbial exposure influences the persistence of long-lived plasma cells in the small intestinal lamina propria. The research will employ imaging and single-cell profiling to define how microbial exposures shape the generation, turnover, and function of long-lived plasma cells by comparing...
- The National Institute of Allergy and Infectious Diseases awarded Albert Einstein College of Medicine $780,787 on January 27, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on how T cell receptor recognition of peptide ligands shapes memory CD8+ T cell programming. The research will identify features of T cell epitopes, T cell receptor structural modes of recognition, T cell receptor signaling pathways, and genetic and epigenetic regulators...
- The National Institute of Allergy and Infectious Diseases awarded Yale University $662,465 on February 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop durable and broadly protective respiratory mucosal immunity against coronaviruses through next-generation intranasal booster vaccines. The research investigates mechanisms by which a mucosal booster vaccine admixed with mastoparan-7 (a mast cell agonist adjuvant) and CPG (a toll-like receptor 9...
The National Institute of Allergy and Infectious Diseases awarded Albany Medical College $633,136 on July 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate lung protective immunity elicited by a parental Yersinia-vesicle vaccine against pneumonic plague. The award funds research to decipher immune mechanisms in the lung following immunization with the MV46-LCRV vaccine candidate and upon pulmonary Yersinia pestis challenge. The project examines how intramuscular immunization with Yersinia outer membrane vesicles remodels lung immunity, with particular focus on lung T cells, alveolar macrophages, and their interrelation. Prior studies indicate the vaccine induces robust adaptive responses in systemic and lung mucosal compartments, significant elevation of alveolar macrophage numbers, and short- and long-term protection against pulmonary Y. pestis challenge; this work aims to clarify the cellular and mechanistic underpinnings to support development of effective pneumonic plague vaccines. Work is performed in Albany, New York. The period of performance runs through June 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $633.1k | 7/23/26 |