Project Grant R01AI200929
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded Purdue University $239,023 on August 21, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop covalent phosphatidylinositol 4-kinase (PI4K) inhibitors targeting malaria parasites. The project executes hit-to-lead optimization of high-priority molecular scaffolds against Plasmodium species that inhibit...
- The National Institute of Allergy and Infectious Diseases awarded Purdue University $248,814 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) for hit-to-lead drug development targeting Acanthamoeba keratitis. Purdue will optimize a novel chemical class of benzoxazepinoindazole inhibitors to develop potent drug candidates for treating Acanthamoeba keratitis, a difficult-to-resolve eye infection caused by free-living amoeba exposure during improper...
- The National Institute of Allergy and Infectious Diseases awarded Purdue University $229,127 on June 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop CDC14 phosphatase inhibitors as novel antifungal agents. The project addresses invasive fungal diseases, which contribute to approximately 3.8 million deaths annually, particularly among immunocompromised populations. The work optimizes chemical compounds that selectively inhibit CDC14, a fungal protein...
- The National Institute of Allergy and Infectious Diseases awarded Purdue University $498,154 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to fund research into signaling mechanisms governing chimeric antigen receptor T cell activation. The research addresses a critical gap in understanding how CAR T cells recognize and eliminate target cells while avoiding off-target activation and collateral damage. CAR T cells express artificial receptors...
- The National Institute of Allergy and Infectious Diseases awarded Oregon State University $495,688 on February 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct mechanistic and structural studies of ureido bond formation in the biosynthesis of three families of bioactive bacterial natural products: anabaenopeptins, syringolins, and muramycins. The work dissects how bacteria assemble these ureido-containing molecules through non-ribosomal peptide...
- Federal Project Grant Award Summary Purdue University received a $406,260 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 1, 2025, through June 30, 2027. The award supports the development of a novel computational framework for B-cell epitope prediction based on immune-induced selection signatures. The project will deliver two primary products: (1) a comprehensive antigen...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $474,363.00 to Rowan University to develop novel antimicrobial peptides inspired by the clinically approved compound daptomycin. The goal is to create new peptide molecules that mimic daptomycin's key mechanisms of action, such as calcium binding and lipid membrane disruption, while improving resistance to...
- The National Institute of Allergy and Infectious Diseases awarded The University Corporation $147,500 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct a multi-scale study of antimicrobial peptide action in non-standard bacterial growth states. The project addresses how antimicrobial peptides (AMPs)—immune-derived molecules that kill bacteria by disrupting membranes and modulate host immune responses—perform under physiologically relevant...
- The National Institute of Allergy and Infectious Diseases awarded the University of Notre Dame DU Lac $709,532 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct systematic research into the cytoplasmic pathway for peptidoglycan recycling in Pseudomonas aeruginosa, an antibiotic-resistant gram-negative bacterial pathogen responsible for recurrent lung infections in cystic fibrosis patients. The work addresses two specific aims. The first...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services, awarded $148,614 to Massachusetts Institute of Technology on January 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The recipient will develop glycopolymers designed to enhance interactions between immune cells and pathogenic bacteria, creating "cellular glues" that leverage the body's innate immune mechanisms as an alternative to...
The National Institute of Allergy and Infectious Diseases awarded Purdue University $442,500 on September 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop antimicrobial agents derived from aapeptide biomaterials targeting drug-resistant bacterial infections. The research addresses antimicrobial resistance identified by the World Health Organization as a major twenty-first-century threat. Purdue will develop small-molecule scorpion-like amphipathic peptidomimetic biomaterials that mimic host-defense peptides, which kill bacteria by disrupting their membranes rather than targeting metabolic pathways—a mechanism that reduces the likelihood of bacterial resistance development. The work focuses on optimizing current lead compounds for greater potency and broad-spectrum activity against multidrug-resistant bacterial strains. A hydantoin derivative developed through this approach has already been licensed to a pharmaceutical company for further development. The award period runs from September 3, 2026, through August 31, 2031, with work performed in West Lafayette, Indiana. This is a project grant, a common assistance type under the program supporting research by named principal investigators at universities and research institutions. The Allergy and Infectious Diseases Research program funds innovative research addressing urgent and emerging infectious, immunologic, and allergic disease challenges through competitive application and peer review.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $442.5k | 9/3/26 |