Project Grant R01AI198576
- The National Institute of Allergy and Infectious Diseases awarded Yale University $2.334 million on June 17, 2026, for research under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds investigation of celiac disease pathogenesis and activity assessment through an integrated three-pronged laboratory approach. Project 1 applies advanced technologies including pan-expansion microscopy, enhanced focused ion beam-scanning electron microscopy, immunopeptidomics,...
- The National Institute of Allergy and Infectious Diseases awarded The Leland Stanford Junior University $166,425 on August 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant K99AI201798). The recipient will systematically map the antigen specificity of approximately 1,000 T cell receptors (TCRs) from intestinal CD4+ T cell populations to characterize how microbiota and dietary components determine CD4 T cell fate. The research employs a gnotobiotic...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $127,926 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize autoreactive B cells and their roles in systemic lupus erythematosus (SLE) pathogenesis using immune organoids. The research investigates how autoreactive B cells transition from a...
- The National Institute of Allergy and Infectious Diseases awarded the University of Pittsburgh $237,919 on May 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on microbial regulation of tolerogenic dendritic cells in oral tolerance as it relates to celiac disease. The research addresses loss of oral tolerance to gluten in celiac disease, which is triggered by proinflammatory dendritic cells that promote inflammatory T helper 1 responses...
- The National Institute of Allergy and Infectious Diseases awarded The University of Texas Southwestern Medical Center $661,009 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the genetic and immunological role of ABCF1 in celiac disease and autoimmunity. The research characterizes how rare pathogenic variants in ABCF1 contribute to immune dysregulation in celiac disease and related autoimmune conditions. Preliminary work identified...
- The National Institute of Allergy and Infectious Diseases awarded The Leland Stanford Junior University $180,929 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to model immune and microbiota development in predicting child health outcomes. The research integrates longitudinal immune and microbiota monitoring to predict beneficial immune states associated with strong responses to routine immunization in children. The project leverages existing...
- The National Institute of Allergy and Infectious Diseases awarded The Leland Stanford Junior University $434,090 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of low-abundance bacterial species in gut microbiome colonization resistance against Clostridioides difficile infection. The project evaluates how low-abundance commensal species contribute to microbiome stability and pathogen resistance using synthetic microbial...
- The National Institute of Allergy and Infectious Diseases awarded the University of Pittsburgh $201,608 on June 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how enteric viruses trigger loss of oral tolerance and inflammation. The research examines how type 1 Lang (T1L) strain reovirus, a gut-infecting virus, initiates a specific form of cell death called necroptosis in intestinal epithelial cells, ultimately shifting dendritic cells toward...
- The National Institute of Allergy and Infectious Diseases awarded The Leland Stanford Junior University $423,500 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, R21AI197001) to investigate how oxygen and bile acid processing shape the small intestinal microbiome and colonization resistance. The research addresses a critical knowledge gap: most microbiome studies rely on fecal samples that reflect the large intestine, not the functionally distinct...
- The National Institute of Allergy and Infectious Diseases awarded the University of Washington $191,268 on August 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the epigenetic architecture of autoimmune risk loci, with focus on multiple sclerosis and type 1 diabetes. The award funds research into noncoding genetic variants and their role in autoimmune disease susceptibility. The project uses long-read chromatin fiber sequencing techniques...
The National Institute of Allergy and Infectious Diseases awarded The Leland Stanford Junior University $769,846 on August 1, 2026, to support organoid modeling of tissue-resident immunity in celiac disease under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds development and mechanistic study of air-liquid interface organoids derived from patient duodenal endoscopic biopsies that preserve intestinal epithelium together with tissue-resident T and B lymphocytes, plasma cells, myeloid cells, and mesenchyme without artificial reconstitution. These organoids recapitulate gluten-induced pathology and enable investigation of mechanisms by which gluten-derived deamidated gliadin peptides activate pathogenic CD4+ T cells and induce cytotoxic CD8+ T cells to destroy intestinal epithelium. The project, led by PI Calvin Kuo with co-investigators Mark Davis, Nielsen Fernandez-Becker, and Antonio Santos, will test hypotheses regarding gluten-induced anti-tissue transglutaminase autoantibody production, the role of MHC-II helper T cell stimulation, and interleukin-7 as a mediator of gliadin-induced epithelial cell killing. Performance occurs at Stanford's Palo Alto, California campus. The five-year award runs through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $769.8k | 7/23/26 |