Project Grant R01AI192641
- Federal Grant Award Summary The University of Connecticut Health Center received a $825,050 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective June 1, 2026, through May 31, 2031. This five-year research initiative will investigate glycosylated RNA (glycoRNA) and its role in controlling immune homeostasis. The research will characterize the structural features of glycans that...
- Federal Grant Award Summary The University of Connecticut Health Center received a $523,037 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 1, 2026 through January 31, 2031. The award funds investigator-initiated biomedical research examining the role of unanchored ubiquitin chains in non-canonical inflammasome signaling, with particular emphasis on...
- Federal Grant Award Summary The University of Connecticut received a $427,604 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded on August 19, 2025. The award funds basic biomedical research directed by investigators at UConn's Storrs campus to elucidate the molecular mechanisms underlying conoid extrusion in Toxoplasma gondii, a parasitic pathogen that chronically infects...
- Federal Grant Award Summary The University of Connecticut received a $447,604 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on February 24, 2026, with a completion date of January 31, 2028. The research project focuses on investigating the molecular mechanism of action of small molecule compounds that regulate the GTPase (guanosine triphosphatase) activity of BipA, a...
- Federal Grant Award Summary The University of Connecticut Health Center received a $457,875 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 10, 2026, with completion targeted for January 31, 2028. This award supports biomedical research investigating the independent gene regulation functions of the Borrelia burgdorferi (Lyme disease spirochete) BosR protein outside...
- Federal Project Grant Award Summary The University of Connecticut Health Center received a $1.28 million Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective September 1, 2025, through August 31, 2030. This award supports investigator-initiated biomedical research aimed at deciphering the regulatory networks of Borrelia burgdorferi (the causative agent of Lyme disease) as the...
- Federal Grant Award Summary The University of Connecticut Health Center received a $457,875 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2027. The award funds basic biomedical research investigating fundamental aspects of Treponema pallidum (TPA) pathogenesis, specifically examining nutrient acquisition mechanisms and cyclic nucleotide...
- Federal Project Grant Award Summary The University of Connecticut Health Center received a $457,875 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 1, 2025, through June 30, 2027. The award supports biomedical research investigating the role of the RpoS (sigma factor) regulatory protein in the persistence of Borrelia burgdorferi, the spirochete bacterium that causes...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Feinstein Institutes for Medical Research a $324,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 5, 2025, with a completion date of July 31, 2030. This award supports investigator-initiated biomedical research examining the mechanisms underlying dysregulated host immune responses in sepsis compared to regulated immune responses in...
- Federal Grant Award Summary Dartmouth College, through its Office of Sponsored Projects, received a Project Grant award of $105,076 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award was obligated on December 20, 2025, with a completion date of July 31, 2027, and supports research to be conducted in New Hampshire. The grant funds basic biomedical research investigating the dual functionality...
The University of Connecticut Health Center received a $624,375 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 2, 2026, for research continuing through May 31, 2031. This award supports investigator-initiated biomedical research examining the regulation of antibacterial interferon defense mechanisms, specifically focusing on how MIT family transcription factors (TFE3 and TFEB) direct Type I interferon responses against bacterial pathogens such as enterohemorrhagic Escherichia coli (EHEC). The research addresses a critical knowledge gap regarding host factors essential for initiating Type I interferon responses against bacterial infections. The funded research project will generate scientific knowledge regarding the role of MIT family transcription factors in innate immune defense, with potential implications for developing novel therapeutic strategies for bacterial infections where antibiotic treatment is contraindicated or ineffective. The project encompasses basic science investigations into pathogenic mechanisms and immunological pathways, contributing to the advancement of understanding disease mechanisms and therapeutic approaches in infectious disease research within the broader scope of NIAID's mission to support biomedical research addressing infectious diseases and related immunologic disorders.Federal Grant Award Summary
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