Project Grant R01AI192491
- The National Institute of Allergy and Infectious Diseases awarded Drexel University $222,786 on June 24, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop injectable acellular hydrogels for local immunoregulation and tolerance in autoimmune diseases. The research addresses the imbalance of pro-inflammatory and autoreactive T cells against regulatory T cells (Tregs) that underlies autoimmune disease onset and progression. Existing systemic immunosuppression...
- The National Institute of Biomedical Imaging and Bioengineering awarded Drexel University $547,836 on August 15, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop polymer-derived nanocarriers for messenger RNA delivery that induce antigen-specific immune tolerance. The project addresses allergic and autoimmune diseases by engineering polymeric nanoparticles that co-deliver antigens and mRNAs encoding...
- The National Institute of Allergy and Infectious Diseases awarded Drexel University $624,806 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and characterize nanotrap therapeutic vaccines for HIV treatment. The project, titled "Nanotrap Therapeutic Vaccines for HIV Virion Capture and Infected Cell Targeting" (R01AI203404), will engineer liposomal nanoparticles displaying multivalent CD4 mimetic ligands designed to capture...
- The National Institute of Allergy and Infectious Diseases awarded the University of North Carolina at Chapel Hill $530,480 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop intravenously administered acetalated dextran microparticles for treating multiple sclerosis. The recipient will conduct basic and translational research on biopolymeric acetalated dextran microparticles designed to target B cells in vivo and induce antigen-specific...
- Federal Grant Award Summary Drexel University received a $152,250 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 16, 2025, with completion targeted for June 30, 2027. The research project, titled "Placating Death Eaters: Tuning Macrophage Metabolism and Phenotype via Nanoparticles," develops cyclodextrin nanoparticles (CDNPs) as a delivery mechanism to modulate...
- The National Institute of Allergy and Infectious Diseases awarded Scripps Research Institute $552,000 on August 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct functional characterization of dendritic cell heterogeneity for T cell-inducing immunotherapies. The research addresses vaccine development for intracellular pathogens including HIV/AIDS and malaria by investigating the distinct roles of type 1 and type 2 conventional dendritic cells in...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the Department of Health and Human Services, awarded $300,000 to the University of Texas Southwestern Medical Center on September 10, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds development of immune checkpoint-engineered oligodendrocytes as a cell-based therapeutic approach for multiple sclerosis. The research builds on prior work demonstrating that immune...
- The National Institute of Allergy and Infectious Diseases awarded the University of Maryland, College Park $722,262 on February 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on guiding innate signaling in skin with microneedle arrays to promote durable antigen-specific tolerance during autoimmunity. The project runs through January 31, 2031, with work performed at College Park, Maryland. The research addresses autoimmune diseases including...
- The National Institute of Allergy and Infectious Diseases awarded The Washington University $113,595 on January 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on classical dendritic cells and cardiac allograft tolerance. The research uses single-cell RNA sequencing to investigate how co-stimulation blockade—specifically CTLA-4 Ig and anti-CD40L neutralizing antibodies—modulates immune responses in transplanted hearts compared to traditional...
- The National Institute of Allergy and Infectious Diseases awarded The Children's Hospital of Philadelphia $906,255 on July 8, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to discover and characterize novel genes regulating follicular helper T cell function in antibody responses. The research combines variant-to-gene mapping approaches in human follicular helper T cells to identify disease-associated genetic variation influencing B cell antibody responses. Aim...
The National Institute of Allergy and Infectious Diseases awarded Drexel University $584,755 for a Project Grant (R01AI192491) on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds the engineering of biomaterial-based dendritic cell therapies for antigen-specific immune tolerance. The project develops sustained-release microparticles incorporating an immunomodulatory combination (PPI9: CEP-33779 and R848) to generate long-lived, potent tolerogenic dendritic cells ex vivo that induce regulatory T cells in vitro and in vivo, including testing in CNS1-deficient mouse models. A sub-aim investigates an allogeneic dendritic cell therapy combining sustained PPI9 delivery with MHC I silencing. The second major aim optimizes nanoparticle formulations that selectively target lymph-node-resident dendritic cells using charge-modulated and PEG-stabilized liposomes, with top candidates evaluated in experimental autoimmune encephalomyelitis models. The work establishes design rules linking dendritic cell persistence or lymph-node targeting to regulatory T cell induction to enable next-generation antigen-specific tolerance therapies. Performance occurs in Philadelphia, Pennsylvania. The period of performance runs from September 1, 2026 through August 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $584.8k | 8/18/26 |