The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $894,735 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to St. Jude Children's Research Hospital Inc. The grant period runs from February 26, 2025 to January 31, 2029. The project aims to develop a novel positron emission tomography (PET) imaging agent, [18F]fluoromannitol, to specifically identify bacterial infection, particularly osteomyelitis, in patients with sickle cell disease. The research involves developing a streamlined radiosynthesis for the agent, validating its ability to diagnose bacterial infection in a sickle cell disease mouse model, and evaluating its potential to quantify antibiotic efficacy. The project will culminate in first-in-human studies to assess the biodistribution and safety of [18F]fluoromannitol in healthy volunteers, in support of future clinical research on sickle cell osteomyelitis and other bacterial infections.
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