The University of Pennsylvania, through its Clinical Practices division, has been awarded a $1,024,897 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to conduct research on the role of immune system signaling in controlling intestinal and systemic Yersinia bacterial infections.
Specifically, the research aims to: 1) define how monocyte-specific TNF receptor signaling contributes to expression of IL-1 in innate immune cells, 2) dissect the requirement and sufficiency of IL-1 receptor signaling on intestinal epithelial cells in controlling Yersinia infection, and 3) utilize a new chromosomal barcode library and computational toolkit to analyze Yersinia replication and dissemination dynamics in normal and immune-compromised settings. This 5-year research project, which commenced on March 3, 2025, is expected to provide critical insights into the immune mechanisms underlying Yersinia infection and inform the development of potential treatments.
Generated 3/18/25, 5:13 AM