Project Grant R01AI191417
- Federal Project Grant Award Summary Massachusetts General Hospital received a $364,484 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 25, 2025, with completion targeted for June 30, 2027. The grant supports research to develop and evaluate soluble guanylate cyclase (SGC) agonists as novel bronchodilators for treating respiratory syncytial virus (RSV)-induced bronchiolitis...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital $807,330 on August 12, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on potent antibody protection against Plasmodium falciparum and Plasmodium vivax malaria. The project, which extends through July 31, 2030, focuses on identifying and characterizing highly potent human antibodies targeting the...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital $691,293 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a one-year project grant effective January 1, 2026 through December 31, 2026. The research project, titled "Impact of In Utero HIV and Antiretroviral Exposure on the Placenta and Birth Weight," will investigate the effects of antiretroviral therapy (ART) and HIV...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital a $676,666 Project Grant on September 3, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop an advanced influenza messenger ribonucleic acid (mRNA) vaccine delivery system. The research will focus on constructing a trivalent self-amplifying mRNA flu vaccine encapsulated within liposomes and delivered via a microneedle array...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $3.3 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded on August 11, 2025, with completion targeted for July 31, 2029. This research project will examine the real-world uptake, effectiveness, and cost-effectiveness of newly approved respiratory syncytial virus (RSV) prevention...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital $453,750 on June 17, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop an innovative high-throughput airway organoid screening platform. This research project, scheduled for completion by May 31, 2027, focuses on identifying novel mechanisms of communication between airway epithelial cells (AECs) and intraepithelial...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $489,500 to Boston Children's Hospital under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a two-year project beginning July 9, 2025, and concluding June 30, 2027. This Project Grant supports fundamental research aimed at overcoming technical obstacles in the structural elucidation of B cell antigen receptor (BCR) assembly and lateral interaction. The research...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital (MGH) a $453,750 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025 through July 31, 2027. This award funds research into the cellular and molecular mechanisms of neutrophil swarming behavior in response to Pseudomonas aeruginosa infections. The project develops an ex vivo model to study how...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital a Project Grant of $800,557 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective February 19, 2026, with a completion date of January 31, 2031. This grant supports investigator-initiated biomedical research focused on understanding how the gram-positive pathogen Staphylococcus aureus manipulates inflammasome activities critical...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases awarded Trustees of Boston University (Boston University Medical Campus) a Project Grant of $189,276 effective August 1, 2025, through July 31, 2030, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This award supports the development and application of an agent-based mathematical modeling framework to characterize Respiratory Syncytial Virus (RSV) burden and evaluate prevention...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital a $3.86 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 6, 2026, with a completion date of January 31, 2030. The MARVELOUS (Maternal RSV Vaccination—Evaluating Optimal Immune Responses) study will conduct comprehensive immunological research on maternal Respiratory Syncytial Virus (RSV) vaccination and its protective effects on infants. The project will examine fetal and neonatal immune responses to maternal RSV vaccination, characterize placental and breastmilk antibody transfer mechanisms, and evaluate how vaccination timing, antibody properties, and immune characteristics influence infant protection through six months of age. The research will utilize a cohort of 400 pregnant women and their infants to assess fetal cellular responses isolated from placental villi and cord blood, profile antibody characteristics including immunoglobulin G (IgG) subclasses, Fc-receptor binding, glycosylation profiles, and neutralizing capacity through both in vivo and in vitro assays. The findings are expected to identify key determinants of placental and breastmilk antibody transfer and define optimal maternal vaccination timing to maximize infant protection from RSV and related infections. Performance of the grant will take place at Massachusetts General Hospital's Research Management Division in Boston, Massachusetts.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.9m | 2/6/26 |