The National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) awarded Emory University a 5-year, $744,977 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to explore the role of tissue-resident memory T cells in protecting against respiratory virus transmission. The research aims to define the cellular interactions and molecular mechanisms by which these T cell populations limit the propagation of respiratory virus infections in the respiratory tract. This work will utilize mouse and guinea pig models of respiratory virus transmission to characterize the key features of tissue-resident memory T cells that confer protection, with the goal of informing the rational design of future cell-mediated vaccines against respiratory pathogens.
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