Project Grant R01AI190301

Award Date 5/1/25
Completion Date 4/30/30
Dollars Obligated $735K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Illinois, USA
Similar Awards
This $785,511 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports the University of Chicago's research to develop induced pluripotent stem cell (iPSC)-derived macrophages as a model to study the genetic basis of inter-individual variation in immune responses to pathogens. The award has an initial term from January 2025 through December 2029. The research aims to...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $3,112,961.00 to the University of Chicago to study the mechanisms underlying exceptional protective immune responses that control persistent viral infections. The research aims to identify novel modulators of the major histocompatibility complex class II (MHC-II) antigen presentation pathway, which are key...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will provide $643,718 to the University of California, Los Angeles (UCLA) to study the role of the IRF regulatory network in shaping macrophage immune responses. The 5-year research project aims to elucidate how transcription factors like IRF1, IRF3, and IRF7 remodel the macrophage epigenome and chromosome organization in a...
The National Institute of General Medical Sciences (NIGMS) awarded a $2,070,444 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the University of Chicago to conduct research characterizing the genetic and evolutionary determinants of population variation in transcriptional responses to pathogens. Over the project period from July 10, 2024 to April 30, 2029, the university will explore the effects of natural selection and genetic ancestry on gene expression, epigenetic...
The University of Chicago was awarded a $884,454 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant, awarded on June 6, 2024, supports research to perform clonal analysis of naturally occurring IL-10-producing TR1 regulatory T cells in mice. The objectives are to define the T cell receptor (TCR) repertoire, reactivity, differentiation trajectory, and transcriptional profile of...
This $162,512 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to determine how pathogen exposure and inflammation impact the expansion and function of long-lived effector CD8 T cells in the memory compartment. The award will enable the Regents of the University of Minnesota, a prominent land-grant research institution, to conduct experiments to identify...
This $831,755 federal Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research, supports research at New York University (NYU) School of Medicine to investigate the role of lung-resident macrophage subsets in regulating type 2 immune responses and trained immunity. The research aims to enhance understanding of how specialized interstitial macrophages mediate critical functions in the lung, particularly...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,225,986 cooperative agreement to the University of Chicago under the Allergy and Infectious Diseases Research program (CFDA 93.855). The funding will support a research project to investigate the factors that determine strong, durable, and broadly protective adaptive immune responses to influenza vaccination, particularly in individuals with prior influenza virus exposure. The project aims to develop statistical and...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,601,319.00 to Emory University to conduct research on the epigenetic regulation of early B cell differentiation and its impact on humoral immunity. The research aims to determine the transcriptional and epigenetic mechanisms that drive B cell fate decisions between antibody-secreting cells and memory B...
This $2,483,910 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support three integrated projects at The Washington University focused on defining novel disease mechanisms related to genetic errors of immunity (GEIs). The first project will map genes prone to autosomal random monoallelic expression (ARMAE) in the immune system and evaluate the epigenetic regulation of this...

This Project Grant award of $735,078 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to unravel the molecular mechanisms of innate immune memory in humans. The University of Chicago, the award recipient, will use combined expertise in functional genomics, computational biology, human immunology, and infectious diseases to address three key questions: (1) What are the epigenetic changes induced by trained immunity adjuvants in human myeloid and lymphoid progenitor cells? (2) How can trained immunity-induced epigenetic changes be transmitted from hematopoietic stem cells to differentiated immune cells? and (3) What are the genetic and molecular determinants of inter-individual variation in trained immunity? The research will employ single-cell gene expression and chromatin accessibility profiling to measure epigenetic and transcriptional signatures, as well as response quantitative trait loci (QTL) mapping to identify factors associated with variation in trained immunity. This work aims to yield unique insights into the molecular mechanisms necessary for inducing long-lasting trained immunity in humans.

Generated 5/13/25, 2:05 AM