The National Institute of Allergy and Infectious Diseases (NIAID) awarded Emory University a 5-year, $597,542 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on the metabolic and epigenetic regulation of skin-resident regulatory T cells (Tregs). The project aims to dissect the specific metabolic programs governing the homeostasis of skin Tregs and elucidate how these metabolic adaptations impact the transcriptional and epigenetic reprogramming of this unique Treg population. The research will leverage single-cell metabolic profiling, CRISPR/Cas9-based in vivo screening, and Treg-specific genetic mouse models to advance the understanding of how tissue-resident Tregs adapt to environmental cues like hypoxia to maintain immune tolerance and suppress inflammation in the skin microenvironment. This work has the potential to transform the field's knowledge of Treg tissue adaptation and provide insights into the role of metabolism in regulating Treg function, with implications for managing inflammatory skin diseases.
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