Project Grant R01AI190168
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $859,992 Project Grant to Yale University for the "Molecular Investigations of HIV-1 Maturation Pathways and Inhibitor Actions in situ" research project. The grant, funded under NIAID's Allergy and Infectious Diseases Research Program (CFDA 93.855), aims to use advanced in-situ cryo-electron microscopy and tomography techniques to visualize the structural transitions of the HIV-1 virus during the maturation...
- This Project Grant award of $3,192,404 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research on immunomodulation in adeno-associated virus (AAV) gene therapy. The research aims to better understand, model, and manage immune responses that can arise from systemic dosing of recombinant AAV vectors, which pose a major challenge in the treatment of monogenic disorders using this gene...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $518,400 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The New York Structural Biology Center, Inc. (NYSBC) to determine the three-dimensional structure of a unique bipartite internal ribosome entry site (IRES) from the Giardia lamblia virus (GLV). This IRES violates the typical paradigm for viral IRES elements, as a significant portion resides within the coding region. The...
- This $3,170,096 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports research to develop the L7AE protein as a therapeutic for treating infections caused by the Orthomyxoviridae virus family, which includes influenza. The key research aims are: (1) investigating the mechanism of action of L7AE on various Orthomyxoviridae family members, (2)...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $147,486 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The New York Structural Biology Center, Inc. (NYSBC) to conduct research on the structural diversity and functional implications of viral RNA translation initiation elements, known as internal ribosome entry sites (IRES). The research aims to define the structural heterogeneity of HCV-like IRES elements across multiple...
- The federal Project Grant award of $3,436,588.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The award supports research to investigate the role of the TLE3 transcription cofactor in regulating the function and persistence of CD8+ T cells during chronic viral infections and cancer. The research aims to molecularly reconstruct the T cell exhaustion process and identify therapeutic...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $300,000 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to Optimeos Life Sciences, Inc., a biotechnology company in New Jersey. The grant supports the development of an off-the-shelf nanoparticle platform for in vivo stem cell gene therapy to treat severe immune deficiencies such as ADA-SCID. The project aims to deliver a DNA payload in nanoparticles targeting hematopoietic stem...
- This federal Project Grant award of $729,006 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research on how the adenovirus manipulates host cellular RNA binding proteins (RBPs) to facilitate viral replication and overcome host defenses. The project, conducted by the Children's Hospital of Philadelphia Research Institute, aims to define the mechanisms by which the adenovirus late protein L4-100K alters RBP...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $400,125 Project Grant to Meharry Medical College under the Allergy and Infectious Diseases Research program (CFDA 93.855) to elucidate a novel mechanism by which HIV-1 evades the APOBEC3G antiviral function through selective viral RNA packaging. The research aims to: 1) compare APOBEC3G-related mutation profiles in infected cells and viral particles, focusing on key RNA packaging elements, and 2) investigate the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $743,752 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Utah. The grant will support research to define how chronic antigen stimulation contributes to epigenetic programming that drives dysfunction in virus-specific CD4+ T cells during chronic viral infection. The project aims to use highly innovative in vivo models and whole genome DNA methylation sequencing...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $605,895 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to Rutgers, The State University to conduct research on cryogenic nanoimaging of adeno-associated virus (AAV) infection and packaging. The project aims to directly observe key steps in AAV infection and transduction using cryo-electron microscopy techniques, in order to determine the structural basis for barriers to effective AAV-based gene therapy delivery. The research will seek to elucidate the mechanisms by which the viral genome leaves the capsid and identify differences between successfully transduced virions and those that get "stuck" during the infection process. Additionally, the project will explore chemical and genetic modifications to AAV packaging to potentially increase the maximum transgene insert length. The award has an ultimate completion date of July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $605.9k | 8/8/25 |