The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $682,879 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Medical College of Wisconsin, Inc. (MCW) to conduct research on the impact of human cytomegalovirus (HCMV) infection on human brain development.
The study aims to (1) define transcriptional and cellular disruptions to developing human neural cells caused by HCMV, (2) determine the effects of specific viral proteins in disrupting human brain development, and (3) elucidate the influence of HCMV-infected microglia on human brain development. The researchers will leverage advanced technologies such as bulk, single cell, and spatial transcriptomics, calcium imaging, and microelectrode array analysis to investigate these topics. The five-year project, which began on Jan 24, 2025, seeks to uncover fundamental mechanisms of HCMV's neurodevelopmental impact and inform the development of targeted therapeutic interventions.
Generated 3/4/25, 6:23 AM