Project Grant R01AI189852
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The University of Texas Southwestern Medical Center a Project Grant of $3,278,392 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 21, 2025, for research extending through July 31, 2029. This award supports biomedical research investigating the role of ubiquitin ligases and deubiquitinases in host defense mechanisms against Mycobacterium tuberculosis...
- Federal Project Grant Award Summary Texas A&M University System Health Science Center received a $624,267 Project Grant award (CFDA 93.855, Allergy and Infectious Diseases Research) from the National Institute of Allergy and Infectious Diseases on August 11, 2025, with a completion date of July 31, 2030. The research initiative focuses on developing methods to understand how small molecule compounds penetrate the cellular envelope of gram-negative bacteria, particularly Acinetobacter...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Texas Biomedical Research Institute $905,998 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to evaluate the safety, immunogenicity, and efficacy of a novel attenuated Mycobacterium tuberculosis (MTB) vaccine candidate in the context of HIV co-infection. Commencing June 17, 2025, and extending through May 31, 2030, this project will leverage the institute's...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The University of Southern Mississippi $750,000 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 20, 2025, for a research project extending through August 31, 2029. This Project Grant supports investigator-initiated biomedical research to elucidate the role of extracellular polyphosphate in Mycobacterium tuberculosis antibiotic tolerance. The research aims to...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The University of Texas Southwestern Medical Center a Project Grant of $1,141,359 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective September 11, 2025, with completion targeted for August 31, 2030. This award supports investigator-initiated research to elucidate the mechanisms of Mycobacterium tuberculosis (MTB) transmission through cough-mediated...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston University Medical Campus a Project Grant totaling $245,250 under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 9, 2026 through January 31, 2028. This investigator-initiated research grant supports a two-year study examining the mechanisms of alternative macrophage activation in pulmonary tuberculosis (TB), specifically investigating the phenotypes...
- Federal Project Grant Award Summary Texas A&M Engineering Experiment Station received a $1.24 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded on May 28, 2025, with a project completion date of April 30, 2030. The grant supports fundamental biomedical research investigating rapid stress response mechanisms in gram-negative bacterial pathogens, specifically examining...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $819,998 to The Regents of the University of California, San Francisco on July 16, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This award supports a five-year research initiative (completion date: May 31, 2030) to identify and characterize host cell death factors during Mycobacterium tuberculosis (MTB) infection using proteomics and...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Methodist Hospital Research Institute a $2.71 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 12, 2025, for research extending through May 31, 2029. This award supports the development and characterization of a novel generation of self-adjuvanted messenger RNA (mRNA) vaccines targeting Mycobacterium tuberculosis (MTB), the causative...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $141,712 Project Grant to the University of California, Irvine on February 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This 24-month research initiative, concluding January 31, 2028, focuses on characterizing a novel histidine phosphotransfer regulatory system in Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis. The research...
Texas A&M AgriLife Research received a $698,387 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 1, 2026 through March 31, 2031. The project, titled "Systematic Exploitation of Synergy to Improve Tuberculosis Therapy," focuses on identifying and developing novel combination drug therapies targeting the mycobacterial cell wall. The research employs chemical genetic approaches to discover cell wall metabolic proteins that can be inhibited to produce synergistic effects with existing antimicrobials, combined with structure-guided drug design to develop specific chemical inhibitors and investigate synergistic mechanisms during infection. The deliverables of this five-year research initiative include identification of validated cell wall targets suitable for combination therapy, development of novel chemical compounds demonstrating synergistic activity with current tuberculosis drugs, mechanistic characterization of drug synergy, and evidence-based therapeutic strategies to accelerate tuberculosis combination therapy regimens. The research is positioned to advance the scientific understanding of mycobacterial cell wall biology while generating actionable drug candidates and combination approaches to improve treatment efficacy and clinical outcomes for tuberculosis patients.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $698.4k | 3/27/26 |