Project Grant R01AI189831
- Federal Grant Award Summary Clemson University's Division of Research received a $158,433 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 15, 2025, through April 30, 2027. The grant supports research investigating the metabolic determinants of carbon dioxide tolerance in Cryptococcus neoformans, a pathogenic fungus responsible for approximately 180,000 deaths...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Pittsburgh a $437,250 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) for research on unrecognized azole resistance among Candida parapsilosis causing bloodstream infections. The award, effective February 1, 2026 through January 31, 2028, supports investigator-initiated biomedical research addressing infectious disease mechanisms and...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Pittsburgh a $437,250 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective February 1, 2026, through January 31, 2028. This investigator-initiated research project delivers scientific investigation into Candida glabrata populations during gastrointestinal tract colonization and intra-abdominal candidiasis (IAC), with particular...
- Federal Grant Award Summary Prokaryotics Incorporated received a $299,697 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded September 19, 2025, with a completion date of August 31, 2026. The award supports the development of a mechanistically novel antifungal agent targeting fks1 and cell wall 1-3-D-glucan biosynthesis to address life-threatening fungal infections in hospital...
- Federal Grant Award Summary Dartmouth College received a $346,214 Project Grant award dated June 6, 2025, from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct investigator-initiated biomedical research on Aspergillus fumigatus diagnostics. The research project, with performance at the institution's Hanover, New Hampshire location and completion targeted for February 28, 2027, focuses on understanding...
- Federal Grant Award Summary Clemson University's Division of Research received a $300,000 Project Grant from the U.S. Department of Agriculture's National Institute of Food and Agriculture under the Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310), awarded July 1, 2025, with completion expected June 30, 2027. This seed grant funds the development of integrated pest management (IPM) tactics that combine biorational fungicides with conventional fungicides to manage fungal...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $1,193,457 to the University of Massachusetts Medical School on July 21, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop fungal antigen resources for vaccines and diagnostics. This collaborative project, executed through a consortium involving UMass Chan, the University of Texas at San Antonio (UTSA), and the University of Wisconsin-Milwaukee...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $482,071 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 19, 2026, through January 31, 2031. This award supports investigator-initiated biomedical research examining copper homeostasis in fungal pathogenesis, specifically utilizing Cryptococcus neoformans as a model system to...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $242,250 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 13, 2026, with completion scheduled for January 31, 2028. This research initiative focuses on identifying prognostic biomarkers in invasive candidiasis by developing and validating host gene expression signatures that can...
- Federal Project Grant Award Summary Dartmouth College received a $630,677 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 2, 2026, with completion targeted for January 31, 2031. The research will be conducted at Dartmouth's Hanover, New Hampshire campus in collaboration with the Dartmouth Cystic Fibrosis Research Center. This award funds investigator-initiated...
Clemson University's Division of Research received a $418,378 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 1, 2026 through March 31, 2031. The award supports investigator-initiated biomedical research to advance understanding of fungal drug resistance mechanisms in Aspergillus fumigatus, a pathogenic mold responsible for invasive infections. The research team will deliver scientific knowledge and methodological advances through three primary research aims: characterization of RTM (resistance to toxins/medicines) family proteins and their regulation by long noncoding RNA AFU-182; structure-function analysis of AFU-182 to elucidate mechanisms underlying azole tolerance; and forward-genetics screening in the related fungus Aspergillus nidulans to identify novel factors in azole response networks. The products and services delivered through this award will include peer-reviewed publications documenting novel mechanisms of azole drug response in Aspergillus species, identification of new therapeutic targets to combat the rising threat of azole drug resistance in fungal infections, and expanded scientific understanding of how fungi adapt to antifungal stress through long noncoding RNA-mediated regulatory pathways. These research outputs are designed to inform future strategies for treating invasive aspergillosis and other antifungal-resistant infections, directly advancing public health objectives outlined in the NIAID research program.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $418.4k | 4/1/26 |