This federal Project Grant award of $716,281.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Children's Hospital Corporation, doing business as Boston Children's Hospital. The grant supports research to investigate the mechanisms by which T regulatory cells control allergic skin inflammation, particularly in the context of atopic dermatitis. The research aims to understand how the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $658,426 to The Children's Hospital of Philadelphia (CHOP) to conduct research on chronic STAT3 signaling and its impact on CD8 T cell dysfunction. The key objectives are to investigate the role of the CD39/adenosine axis in impairing CD8 T cell function in the context of STAT3 gain-of-function (GOF) disease, and to...
This $2,654,646 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports a multi-year program to better understand the unique characteristics of the human immune response in early life. The program aims to uncover genetic and developmental determinants of pediatric immunity, examine how immune parameters evolve over childhood, and elucidate how baseline immune states predict responses to...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $130,932 to Harvard Medical School to elucidate the molecular mechanisms underlying the activation and regulation of the inflammasome executioner protein Gasdermin D (GSDMD). The research aims to interrogate this complex system through a combination of biochemistry, biophysics, and cell biology, with the goal...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $578,093 to the University of Massachusetts Medical School to conduct research on a novel human damage-associated molecular pattern (DAMP) receptor, its murine counterpart, and their ligand, GAPDH. The research aims to elucidate the structure, function, and pathophysiology of this DAMP receptor system in both humans...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $729,006 to The Children's Hospital of Philadelphia Research Institute to conduct research on how adenovirus manipulates host RNA-binding proteins to exploit cellular RNA processing pathways and overcome host defenses. The 5-year project, running from January 2025 to December 2029, will employ innovative proteomics and...
This $489,500 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to characterize the role of the ADB2 protein as a novel complement receptor and its contribution to acute lung injury in sepsis. The research, conducted by The Children's Hospital Corporation (dba Boston Children's Hospital), aims to: 1) Determine the binding profile of ADB2 to complement fragments...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides $489,500 to support structural studies of the full-length nucleocapsid (N) protein of SARS-CoV-2. The goal is to determine the high-resolution structure of the full-length N protein in complex with the viral RNA using cryogenic electron microscopy. This research aims to advance the understanding of the...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $489,500.00 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to conduct research on overcoming technical obstacles in understanding the assembly and regulation of B cell antigen receptors (BCRs). The research aims to elucidate the structural details of BCR assembly and...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,483,910 to The Washington University in St. Louis to conduct research on novel genetic mechanisms underlying primary immune regulation disorders. The 5-year project, which commenced on April 8, 2025, aims to investigate three key areas: 1) epigenetic mechanisms leading to autosomal random monoallelic expression in...