Project Grant R01AI187292
- This $427,671 Cooperative Agreement was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), to The General Hospital Corporation (doing business as Massachusetts General Hospital) on July 3, 2025. The purpose of this award is to conduct research to enhance understanding of the phenotypes, endotypes, and mechanisms underlying immediate-onset allergic reactions to antibiotics. The...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $197,640 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), on July 16, 2025. This grant supports research to investigate the contribution of a novel monocyte transcriptional state, termed Monocyte Substate 1 (MS1), to sepsis immunopathogenesis and patient heterogeneity. The project will...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $197,640 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The grant, awarded on August 1, 2025, will support research to determine the drivers of immune checkpoint inhibitor-related myocarditis (IRMYOCARDITIS) and develop therapeutic strategies to modulate interactions between T cells and...
- This $453,750 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), as part of the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), with an award date of June 17, 2025 and an ultimate completion date of May 31, 2027. The grant supports research to define novel mechanisms of communication between airway epithelial cells and intraepithelial airway macrophages, using an innovative high-throughput airway organoid screening...
- This $250,000 Project Grant was awarded on August 21, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports research to develop a prognostic signature of systemic immune dynamics for IgE/Th2-mediated food allergies, using a novel synthetic immunological niche technology. The goal is to distinguish the heterogeneity of allergic responses and monitor immune responses to...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $248,088 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Johns Hopkins University on January 12, 2025. The research aims to examine the role of immunoglobulin E (IgE) and the sugar-binding protein galectin-3 in the activation of basophils, which are immune cells involved in allergic reactions. Specifically, the project will compare galectin-3-dependent basophil activation...
- This federal Project Grant award of $586,250 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research at the University of Massachusetts Medical School (UMass Medical) to investigate the generation and regulation of TFH13 cells that drive pathogenic IgE in allergic conditions. The overarching goal is to elucidate the pathways leading to TFH13 cell differentiation, which play a critical...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $676,666 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for the project "Spatial and Temporal Adjuvant Delivery for Skin mRNA Vaccination". The goal of this project is to determine whether intranasal or intradermal delivery of a newly developed adjuvant can expand the breadth...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $453,750 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The grant, titled "Role of ZNF Proteins in the Establishment and Maintenance of HIV Latency", will support research to evaluate the role of zinc finger (ZNF) proteins in establishing and maintaining HIV-1 reservoirs through...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $800,005 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on the structural basis and functional impacts of genetic variants in G-protein coupled receptors (GPCRs) associated with autoimmune diseases. The project aims to: 1) define the structural basis for impaired...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $806,466 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The 5-year grant, with a start date of August 1, 2025, aims to define the IgG antibody signatures associated with successful peanut oral immunotherapy (OIT) treatment outcomes. The research will characterize the peanut-specific IgG response in peanut-allergic adults who underwent peanut OIT, with the goal of identifying biomarkers that predict the success of OIT and developing novel biologic treatments for food allergies. This grant supports MGH's expertise in conducting advanced biomedical research and developing innovative therapeutic approaches for complex health challenges.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/29/25 | ||
| Not listed | $806.5k | 7/29/25 |