This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $606,501 to Northwestern University to conduct research on the regulation of germinal center homeostasis by the BAF chromatin remodeling complex. The project aims to elucidate the epigenetic control of germinal center B cell differentiation, examine the roles of inflammatory signatures associated with ARID1A loss in disrupting germinal center responses, and define altered immunological landscapes upon ARID1A loss. This research seeks to provide comprehensive mechanistic insights into the role of the canonical BAF complex in establishing robust germinal center responses, which has implications for understanding inflammation and immunity. The award period runs from November 2024 to October 2029.
Generated 1/28/25, 7:02 AM