This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,872,722 over approximately 4 years to the University of South Florida to conduct research on Clostridioides difficile (C. difficile) infection. The research aims to elucidate the roles of penicillin-binding proteins (PBPs) and other peptidoglycan transpeptidases in C. difficile's life cycle and antibiotic resistance, as well as develop new PBP inhibitors to target C. difficile sporulation as a novel approach to address recurrent C. difficile infection. The findings from this comprehensive research project are expected to deepen the understanding of PBPs across bacterial species and provide new insights into the unique properties of C. difficile PBPs, with the goal of facilitating the development of new combination therapies for recurrent C. difficile infection.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $2.9m | 7/23/25 |