This federal Project Grant award in the amount of $800,624, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), aims to develop novel inhibitors of the enzyme thioredoxin glutathione reductase (TGR) for the treatment of schistosomiasis, a parasitic disease affecting over 200 million people worldwide. The key objectives are to optimize the potency, selectivity, and drug-like properties of TGR inhibitors through...
This federal Project Grant award, with a total funding amount of $1,553,810, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to develop a genomic surveillance approach to identify mutations under selection in functional pathways associated with artemisinin resistance in Plasmodium falciparum malaria parasites in Africa. The key objectives are to: 1) identify parasite loci...
This Project Grant award of $402,731 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to increase the number of physician-scientists in pediatrics or obstetrics/gynecology who can apply microbiology, immunology, and research techniques to improve reproductive, maternal, and child health. The grant will support 4 resident physicians to complete one year of laboratory-based training in immunology or...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $152,656 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The grant, titled "Synaptopodin and Its Role in Shigella flexneri Intercellular Spread," will fund research to investigate the molecular mechanisms by which the protein synaptopodin promotes the ability of the Shigella bacteria to spread between cells, a critical process for...
The federal Project Grant award of $700,288 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research to identify genetic factors associated with the development of sexual stages (gametocytes) in the malaria parasite Plasmodium falciparum. The project combines expertise in gametocyte biology, advanced computational genomics, and phenotype comparisons with clinical...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,314,701.00 to support research focused on optimizing dolutegravir-based antiretroviral therapy (ART) in children and adolescents. The primary award recipient is the University of Florida, which will oversee the overall research project. The project includes sub-awards to Kwame Nkrumah University of Science...
This $2,002,422 Cooperative Agreement award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to advance the understanding of systemic and mucosal immunity to vaccination and infection with enteric bacterial pathogens like Salmonella and Shigella in children and adults. The research will use human-based models and specimens from clinical studies to examine the mechanisms underlying...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $615,891 to conduct a multi-year study on sepsis pathobiology in sub-Saharan Africa (SSA). The primary awardee, The Trustees of Columbia University, will lead a team to validate the presence of distinct sepsis "endotypes" in Uganda that reflect host-pathogen features unique to the region. They will...
This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,174,636 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Oregon Health & Science University (OHSU). The funding supports research to optimize the structural features of the antimalarial drug candidate ELQ-596, with the goal of developing a next generation of ELQs for once-monthly oral malaria prophylaxis in humans. The research aims to simplify dosing, improve compliance,...