Project Grant R01AI185069
- This $851,294 Project Grant was awarded on June 20, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Texas Health Science Center at San Antonio. The grant supports research to "Dissect the Mechanism of Altered Immune Responses During Obesity". The key objectives are to investigate how obesity induces expansion of an inflammatory B cell subset, TBET+ CD11C+ B cells,...
- This Project Grant award of $240,750.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research at the Children's Hospital Medical Center in Cincinnati, Ohio to study the contribution of adipose tissue immune cells to influenza pathogenesis. The research aims to better understand the critical processes that govern increased influenza severity in obesity, focusing on the role of immune...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $704,041 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Regents of the University of California at Riverside. The grant supports research to investigate sex-dependent innate immune mechanisms that regulate type 2 immunity and obesity. The research aims to study macrophage-eosinophil interactions and the role of the RELMA protein in protecting against diet-induced obesity and...
- This $556,843 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to advance the understanding of the extrafollicular (EF) B cell response and its role in immunity. The project aims to investigate how the EF response, which produces rapid expansion and differentiation of plasma cells, differs from the more well-studied germinal center (GC) response. Key focus...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $148,880 Project Grant to St. Jude Children's Research Hospital Inc. under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The grant aims to uncover defects in the cellular and genetic machinery of germinal center reactions that impair the ability of obese individuals to sustain long-term B cell responses to the influenza A virus vaccine. The research will phenotypically profile...
- This $107,010 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program supports research into the impact of diet-induced obesity on immune responses to enteric viral infections, specifically norovirus. The principal investigator's preliminary data indicates that mice fed a high-fat diet prior to norovirus infection clear the infection faster than control mice, suggesting obesity may enhance...
- This $451,000.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program, supports research to investigate the manipulation of antibody responses by a retrovirus. The research aims to enhance understanding of how pathogens can directly or indirectly modulate B cells, which play a critical role in providing long-term protective immunity. Specifically, the study will examine...
- This $489,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research grant program (CFDA 93.855), supports research to overcome technical obstacles in understanding the assembly and regulation of B cell antigen receptors (BCRs). The award aims to develop effective adaptive immunity following infection and vaccination by engineering appropriate cell lines and utilizing native membrane environments to study BCR...
- The University of Southern California received a $162,486 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to engineer B cells for enhanced HIV control. The 4.5-year project, which began on February 1, 2025, aims to develop an approach to provide necessary T cell help and produce broadly neutralizing antibody-engineered B cells that would be functional in people living with HIV. Key objectives include...
- This Project Grant award, valued at $778,829.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Emory University. The grant supports research to characterize early-life B-cell and antibody-secreting cell (ASC) development and function, with the goal of uncovering the mechanisms of adaptive immunity at birth. The research aims to validate previous findings on the role of the spleen in...
This $2,190,435 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate obesity-driven alterations in B cell immunity. The primary objectives are to: Characterize the expansion of inflammatory TBET+CD11C+ B cells and associated T follicular/peripheral helper cells in the spleen, liver, and adipose tissue of obese mice, and examine the role of the scavenger receptor CD36 in driving this response. Determine how the expansion of TBET+ B cells during obesity inhibits protective germinal center-based vaccine responses, potentially explaining poor outcomes in vaccinated obese patients. The research utilizes in vitro and in vivo assays, RNA sequencing, flow cytometry, and adoptive transfer experiments to elucidate the underlying immunological mechanisms linking obesity and impaired humoral immunity. This 4-year project, led by researchers at the University of Texas Health Science Center at San Antonio, aims to improve understanding of obesity-induced changes in B cell function and their clinical implications.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.2m | 8/26/25 |