This federal Project Grant award of $612,328 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to enhance the understanding of mast cell lineage commitment and function. The research aims to determine how the transcription factor MITF maintains mast cell-specific gene expression and suppresses basophil-specific gene expression, as well as evaluate the functional deficiencies of mast...
This Project Grant award, valued at $162,000.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research at Indiana University Indianapolis to investigate the role of TGF-beta signaling in regulating T follicular helper (Tfh) cell differentiation and mast cell function, with the goal of better understanding the pathogenesis of allergic diseases. Key objectives include...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $101,577 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Michigan State University (MSU) to investigate the mechanisms by which early life adversity alters mast cell programming and inflammatory activity through modulation of cholesterol metabolism. The research aims to define how early life stress developmentally heightens the mast cell pro-inflammatory phenotype, which...
This federal Project Grant award of $586,250 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research at the University of Massachusetts Medical School (UMass Medical) to investigate the generation and regulation of TFH13 cells that drive pathogenic IgE in allergic conditions. The overarching goal is to elucidate the pathways leading to TFH13 cell differentiation, which play a critical...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Program (CFDA 93.855), provides $497,136 to the Sloan-Kettering Institute for Cancer Research to conduct research on the role of mast cells in regulating the inflammatory pathology of secondary lymphedema. The research aims to investigate how lymphatic injury induces the expression of mast cell activators and Th2-inducing proteins by...
This federal Project Grant award of $716,281.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Children's Hospital Corporation, doing business as Boston Children's Hospital. The grant supports research to investigate the mechanisms by which T regulatory cells control allergic skin inflammation, particularly in the context of atopic dermatitis. The research aims to understand how the...
This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research aimed at understanding the mechanisms underlying mast cell expansion and function in human airway diseases, including asthma and nasal polyposis. The $715,968 award to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System Incorporated, will fund a 5-year project to investigate the...
The federal Project Grant award, identified as F32AI186362, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award, totaling $248,088.00, will be used by The Johns Hopkins University to study the role of immunoglobulin E (IgE) and galectin-3 in the activation of basophils, which are key cells involved in allergic reactions. The research aims to compare galectin-3-dependent basophil...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $936,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The 5-year grant, which commenced on August 12, 2024, will support research to elucidate the regulation and function of tissue-resident eosinophils in allergic microenvironments. The project aims to 1) target cell cycle machinery to manipulate eosinophil specialization, 2) delineate pre-...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $402,731 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to the University of Washington. The objective of this R38 grant is to increase the number of next generation physician-scientists who can apply knowledge of microbiology, immunology, and research techniques to improve reproductive, maternal, and child health. The grant will support 4 physician-scientists in...