The University of California, Los Angeles (UCLA) has been awarded a Project Grant totaling $643,718 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to investigate the role of the IRF regulatory network in reprogramming macrophage innate immune function. The project aims to elucidate how transcription factors like IRF1, IRF3, and IRF7 remodel macrophage epigenomes and chromosomal organization to alter gene expression responses to subsequent stimuli, producing "trained" macrophages with enhanced or dysregulated inflammatory capacity. The research will utilize in vitro and in vivo models to dissect these IRF-dependent mechanisms of innate immune memory in both bone marrow-derived and tissue-resident macrophages. Additionally, UCLA holds a $261,694.92 indefinite delivery contract with the Department of Veterans Affairs to provide animal per diem services supporting VA medical research projects requiring pigs as research subjects.
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