The federal Project Grant award R01AI184976 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $820,623.00 to The Children's Hospital of Philadelphia (CHOP) to study the genetic determinants of SPI1 expression and activity in human germinal center B cells. The research aims to: 1) Identify non-coding elements regulating SPI1 gene expression in human germinal center B cells, 2) Delineate effects of coding variants in SPI1 on autoregulation and expression, and 3) Determine maturational and transcriptional consequences of SPI1 loss-of-function and gain-of-function mutations on differentiated B cells. This 5-year project is expected to advance the understanding of SPI1's critical role throughout B cell development and the implications of SPI1 dysregulation on human health and disease.
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