This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the role of pH in the pathogenesis of type 1 diabetes (T1D). The $429,000 award to the University of Colorado-Denver will fund a 2-year study to examine how changes in acidity within insulin-producing cells lead to the formation of hybrid insulin peptides that may trigger autoimmune attacks on...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $120,255 to the University of Colorado-Denver to investigate the mechanisms by which antigen-specific immunotherapy can suppress autoreactive T cells and prolong islet graft survival in a mouse model of autoimmune diabetes. The research aims to determine the differentiation and functional states of antigen-specific CD4...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $380,000 to the University of Miami to develop a bifunctional RNA therapeutic called PS03. The goal is to use PS03 to modulate PD-L1 expression specifically on B cells in order to induce T cell exhaustion and halt the autoimmune attack in type 1 diabetes. The award period runs from August 1, 2025 to July 31, 2026....
This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to examine the role of B cell-dependent regulatory T cells in maintaining B cell tolerance and preventing autoimmunity. The $807,799 award to the University of Chicago aims to identify B cell-dependent regulatory T cell clones, define their developmental requirements and functions, and determine the...
This federal Project Grant award, R01DK140781, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $1,449,016 award aims to use advanced immunoproteomics technologies to comprehensively screen for microbial infections associated with increased or decreased risk of islet autoimmunity and type 1 diabetes in children participating in the TEDDY study. The project...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $287,000 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to The Regents of the University of California, San Francisco (UCSF). The grant, which runs from April 2025 to March 2027, aims to determine whether genetic mutations that alter IL-17 signaling contribute to the etiology of autoimmune diabetes. The research will use in vitro and in vivo approaches to understand...
This $225,953 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research aims to define the characteristics of human B cells that specifically target foreign glycans, known as xenoglycans. The funded research will use antigen-specific tetramers to identify and isolate distinct populations of xenoglycan-reactive B cells and compare their phenotypic and functional properties to protein-reactive B cells....
This Project Grant award of $1,083,816.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by the University of Colorado-Denver to investigate the role of CD79A as a molecular switch regulating B cell activation and tolerance. The key objectives are to determine how individual CD79A immunoreceptor tyrosine-based activation motif (ITAM) tyrosines impact B cell receptor (BCR) signaling and downstream...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $235,403 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Johns Hopkins University. The funding will support the development of a membrane-reconstituted ZNT8 biosensor to detect cell-surface ZNT8 autoantibodies in the peripheral blood of patients with type-1 diabetes. This novel bioanalytical tool aims to enable the early detection of islet...
This federal Cooperative Agreement award, with a total funding amount of $1,207,770.00 and an award date of January 1, 2025, was granted by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award will support research to investigate the role of genetically-controlled thymic epithelial cell (TEC) and hematopoietic stem cell (HSC) abnormalities in driving the development...