This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support the development of a multivalent mRNA-based malaria vaccine. The $738,445 award to Drexel University will enable the optimization of mRNA vaccine candidates targeting pre-erythrocytic and blood-stage Plasmodium falciparum and Plasmodium vivax malaria parasites. The goal is to concurrently drive durable, antibody-mediated and cell-mediated protective immune responses against multiple stages of the malaria parasite life cycle. Key research activities will include designing, producing, and evaluating mRNA vaccines for the P. falciparum circumsporozoite protein, reticulocyte-binding protein homologue 5, and the 19 kDA C-terminal domain of merozoite surface protein 1. The research aims to determine the potential and limitations of mRNA technology for delivering a multi-component malaria vaccine and provide a foundation to integrate additional targets to advance a multi-stage malaria vaccine. The award period runs from August 1, 2024 to July 31, 2029.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $738.4k | 7/31/24 |