The National Institute of Allergy and Infectious Diseases (NIAID) awarded Emory University a $653,693 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on the structural details of HIV-1 assembly and the mechanism of the capsid targeting compound lenacapavir. The key objectives are to: 1) Develop single particle cryo-electron microscopy techniques to study the immature and mature HIV-1 Gag and capsid lattices, providing insights into the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,225,986 Cooperative Agreement under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Chicago. The grant, titled "Computational Models of Adaptive Immunity to Influenza," aims to investigate factors that determine strong, durable, and broadly protective adaptive immune responses to influenza vaccination, particularly in individuals with prior influenza virus exposure....
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $176,096 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to the University of Illinois to develop a computational toolkit for dissecting HIV drug resistance mechanisms and designing countermeasures. The project aims to leverage protein conformational dynamics to rigorously quantify how specific residues and interactions contribute to drug resistance, enabling the rational design...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $932,750.00 to Emory University to develop and utilize single cell techniques to gain unprecedented insight into West Nile virus (WNV) infection of the lymphatics and spleen. The goal is to better define the cellular targets of WNV infection and understand how the antiviral immune response limits virus...
This Cooperative Agreement award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,171,832 to Emory University to conduct research on influenza immune responses. The project aims to leverage systems biology approaches, including multi-omic analyses and machine learning models, to identify novel correlates of protection against influenza beyond neutralizing antibodies. The research will...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,352,292 Cooperative Agreement under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Illinois. The purpose of the award is to conduct high-resolution profiling and computational modeling of influenza virus-immune dynamics during natural infection. The research aims to identify reliable immune correlates of reduced viral shedding and transmission risk, as well as define how...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $668,569 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Schepens Eye Research Institute, Inc. in Boston, MA. The grant will fund research to characterize and optimize a novel genetic vaccine platform called PARVAX, with the goal of increasing its clinical acceptance and application for pandemic preparedness. Key objectives include investigating the mechanism behind the...
This $2,074,701 federal Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports a multi-year research program at Emory University focused on understanding the fundamental biological and physical processes that drive influenza A virus transmission in humans. The key objectives of the research program are to: 1) Define the dynamics of viral load, immune...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $667,013 to develop and validate deep learning models that can accurately identify antibody-antigen interactions and binding epitopes from massive sequencing data. The key objectives are to leverage recent advancements in high-throughput sequencing, protein structure prediction, and single-cell transcriptomics to...
This Cooperative Agreement award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to develop computational models that can accurately predict the breadth and durability of influenza vaccine-induced immunity. The key objectives are to: 1) capture existing influenza vaccine data and generate new experimental data connecting immune variables to vaccine outcomes; 2) generate...