Project Grant R01AI183302

Award Date 7/24/24
Completion Date 5/31/29
Dollars Obligated $2.1M
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Madison, WI 53715, USA
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This $2,065,600 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research program) aims to investigate the paradox of flavivirus antigenic non-reciprocity. The project will leverage expertise in virology, immunology, epidemiology, and nonhuman primate models to evaluate how serial flavivirus exposures shape antibody repertoires and determine subsequent infection outcomes, with a focus on the emerging Spondweni virus (SPONV). Key objectives include:

  1. Using rhesus macaques to model serial flavivirus exposures and understand antibody correlates of non-reciprocity between SPONV and other flaviviruses like Zika and dengue.

  2. Characterizing antibody specificities and immunodominance in humans and macaques with prior dengue and Zika virus exposures to define determinants of non-reciprocal cross-reactive immunity.

  3. Analyzing serum/plasma samples from the Pediatric Dengue Cohort Study in Nicaragua to assess cross-reactivity with SPONV following different sequences of dengue and Zika virus infections.

The sub-awards to UC Berkeley and the University of Minnesota will support the neutralization assays, B cell sorting experiments, and data analyses required to achieve these aims. The findings from this multidisciplinary research effort are expected to improve risk assessment and inform the development of vaccines and therapeutics for emerging flaviviruses.

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