Project Grant R01AI182769
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $498,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Texas Southwestern Medical Center in Dallas, Texas. This grant will support research investigating the role of a novel fungal RNA molecule, termed Fungal Stimulatory RNA (fsRNA), in modulating intestinal innate immune responses and its impact on gut inflammation. The research aims to uncover the mechanisms...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $164,108 Project Grant to The Regents of the University of California, San Francisco (UCSF) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The project, titled "RNA Regulatory Circuits in Allergic Airway Inflammation," aims to identify RNA regulatory circuits that drive persistent type 2 inflammation in T cells and the airway epithelium in asthma patients. The research...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $784,217 to the Research Foundation of the City University of New York (RFCUNY) - Lehman College to conduct research characterizing how cellular death signaling pathways contribute to both protective and injurious inflammation during bacterial infections. The research aims to identify novel signaling mechanisms...
- This three-year $872,936 project grant from the National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, will fund research into the regulation of the microglial neuroimmune response by long non-coding RNAs. The grantee, Creighton University, will investigate how specific long intergenic non-coding RNAs (lincRNAs) mediate a proinflammatory state in microglia and determine if differential lincRNA expression underlies viral-induced mouse models of...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $743,752 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Utah. The grant will support research to define how chronic antigen stimulation contributes to epigenetic programming that drives dysfunction in virus-specific CD4+ T cells during chronic viral infection. The project aims to use highly innovative in vivo models and whole genome DNA methylation sequencing...
- This federal Project Grant award of $643,718 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how interferon-regulatory factors (IRFs) and STAT transcription factors remodel the epigenome and chromosome organization of macrophages to reprogram their immune responses. The research aims to: 1) dissect the roles of innate immune IRFs in de novo enhancer formation, 2)...
- This $147,486 Project Grant was awarded on May 26, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research by The Trustees of Columbia University in the City of New York, Health Sciences Division, to investigate the role of chromatin-associated RNA processing in early B-cell development. Specifically, the project seeks to determine the mechanism by which the RNA exosome and RNA...
- This Project Grant award of $318,428, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), supports research at Swarthmore College to elucidate the mechanisms and consequences of nucleic acid sensing in human erythroid progenitors. The research aims to investigate both DNA-sensing and RNA-sensing pathways utilized by erythroid progenitors to contribute to antiviral host defense, as well as characterize the downstream...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $147,486 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The New York Structural Biology Center, Inc. (NYSBC) to conduct research on the structural diversity and functional implications of viral RNA translation initiation elements, known as internal ribosome entry sites (IRES). The research aims to define the structural heterogeneity of HCV-like IRES elements across multiple...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is funding research to investigate the mechanisms by which bacterial cholesterol-dependent cytolysins (CDCs) activate the NLRP3 inflammasome, a key innate immune signaling complex responsible for triggering inflammation. The $506,394 award, effective from January 24, 2025 through December 31, 2029, will support studies using...
The Project Grant award of $515,387 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research CFDA program (93.855) supports research to elucidate how long 3' untranslated regions (UTRs) of RNA form and cause autoinflammation. The project aims to investigate the role of neuronal RNA structures, particularly long double-stranded RNAs (dsRNAs), in triggering inflammation through pattern recognition receptors. Specifically, the research will examine how neuron-enriched genes ELAVL2, ELAVL3, and ELAVL4 influence 3'UTR length, dsRNA load, and activation of dsRNA-sensing receptors like MDA5, PKR, and TLR3. This 5-year project, with a planned completion date of July 31, 2030, is being conducted by the Health Sciences Division of Columbia University in New York.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $515.4k | 8/11/25 |