Project Grant DP2AI192036
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $242,185 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Texas A&M Agrilife Research. The grant supports research to investigate the role of RNA structure in regulating developmental RNA editing in pathogenic trypanosomes, such as Trypanosoma brucei. The key objectives are to: 1) Develop a new technique to assess RNA structure under native cellular conditions versus in vitro,...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $164,108 Project Grant to The Regents of the University of California, San Francisco (UCSF) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The project, titled "RNA Regulatory Circuits in Allergic Airway Inflammation," aims to identify RNA regulatory circuits that drive persistent type 2 inflammation in T cells and the airway epithelium in asthma patients. The research...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $132,677 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai (ISMMS) to conduct research on mapping genetic variants associated with inflammatory bowel disease (IBD) to their target genes and functional effects in human macrophages. The project aims to elucidate the transcriptional consequences of IBD candidate genes in monocytes and...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $558,747 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Texas Tech University Health Sciences Center to conduct research on a "Novel Link Between Calcineurin, Amino Acid Permease, and Protein Kinase A in Virulence in Mucor". The research aims to investigate virulence factors in Mucorales fungi that cause the life-threatening condition of mucormycosis, which poses...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $441,375 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Children's Hospital Medical Center (UEI JZD1HLM2ZU83) to conduct research on the "Transcriptional Mechanisms of Chronic Inflammation in Genetically Diverse Tissue Macrophages." The project will focus on understanding the genetic factors and regulatory mechanisms that contribute to the development of metabolic...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $743,752 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Utah. The grant will support research to define how chronic antigen stimulation contributes to epigenetic programming that drives dysfunction in virus-specific CD4+ T cells during chronic viral infection. The project aims to use highly innovative in vivo models and whole genome DNA methylation sequencing...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $112,956 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Texas A&M University System Health Science Center (TAMU HSC) on December 26, 2024. The overall goal of this research project is to define the role of sex-specific traits in influencing energetic trade-offs that underlie innate immune responses and dictate infection susceptibility using the Drosophila melanogaster...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $101,982 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to the University of Massachusetts Medical School (UMMS) to conduct research on the "Temporal Regulation of mRNA Biogenesis in Immune Responses." This 21-month project, running from May 2025 to February 2027, seeks to uncover mechanistic insights into the regulation and impact of stimulus-induced immune mRNA...
- The Project Grant award of $515,387 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research CFDA program (93.855) supports research to elucidate how long 3' untranslated regions (UTRs) of RNA form and cause autoinflammation. The project aims to investigate the role of neuronal RNA structures, particularly long double-stranded RNAs (dsRNAs), in triggering inflammation through pattern recognition receptors. Specifically, the...
- This $200,000 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), to Northwestern University for the project "Targeting MicroRNAs to Modulate Neutrophil Trafficking and Improve Resolution of Gut Inflammation." The research aims to identify novel microRNAs that regulate neutrophil transmigration across the endothelial barrier during gut inflammation, with...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $498,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Texas Southwestern Medical Center in Dallas, Texas. This grant will support research investigating the role of a novel fungal RNA molecule, termed Fungal Stimulatory RNA (fsRNA), in modulating intestinal innate immune responses and its impact on gut inflammation. The research aims to uncover the mechanisms of fsRNA-triggered immunity and its potential contribution to inflammatory bowel diseases using interdisciplinary approaches such as fungal genetic engineering, long-read RNA sequencing, advanced imaging, and in vivo disease models. Ultimately, the findings could reveal new therapeutic targets and open up avenues for developing RNA-based therapies for managing inflammatory diseases. The award period runs from August 7, 2025 through July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $498.0k | 8/5/25 |