This federal Project Grant award, valued at $558,747.00 and provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), supports a research project at Texas Tech University Health Sciences Center (TTUHSC) to investigate the role of calcineurin, amino acid permease, and protein kinase A in the virulence of the fungus Mucor, which causes the life-threatening condition mucormycosis.
The project aims to identify key transcription factors regulated by calcineurin that control the expression of the amino acid permease gene, elucidate the roles of the amino acid permease in Mucor virulence, and demonstrate the link between the amino acid permease and protein kinase A. This research is intended to provide new insights into fungal virulence mechanisms and open up potential avenues for developing novel antifungal drugs to address the high mortality rates and antifungal resistance associated with mucormycosis.
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