This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $612,975 to the University of Pittsburgh to conduct research aimed at achieving long-term acceptance of organ transplants. The project will explore combining T cell costimulation blockade with inhibition of monocyte allorecognition via CD47 as a novel approach to induce durable graft acceptance without excessive immunosuppression side effects. The goals are to develop a translatable animal model demonstrating this approach, and to investigate the mechanisms by which CD47 signaling inhibition leads to monocyte unresponsiveness, with the intent of uncovering new targetable pathways. Insights from this research are expected to have direct relevance for clinical application in organ transplantation. The award period runs from March 2025 through February 2030.
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