The federal Project Grant award R01AI181938, valued at $790,356.00, was provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) to Harvard Medical School to study the role of the gut complement system in protecting against enteric infections. Key objectives of the 5-year research project include: 1) determining the critical cellular sources of intestinal complement component C3, 2) identifying the proteins and pathways involved in gut complement activation and function, and 3) developing a synthetic lipid A molecule to induce high levels of C3 without excessive inflammation. This research aims to uncover new strategies for preventing and treating infectious diarrheal diseases, which pose a significant global health burden. As a sub-grantee, Harvard Medical School has contributed expertise in areas like structural biology, data visualization, biostatistics, and healthcare policy research to support multi-institutional projects funded by federal agencies such as the NIH and Department of Defense.
Generated 3/4/25, 8:29 AM