The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $479,249 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University's Office of Sponsored Research Services Division, a private research university in Missouri. The project aims to investigate the molecular mechanisms regulating neutrophil proinflammatory activity in sepsis, the leading cause of death in intensive care units. Specifically, the study will determine how neutrophil A20 signaling contributes to organ damage in sepsis, utilizing biochemical, cell biological, and intravital imaging approaches. The research project will run from January 2025 through December 2029 and seeks to identify novel therapeutic strategies for treating sepsis by understanding the role of neutrophil recruitment and inflammation in this disease.
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