Project Grant R01AI181112
- The National Institute of Allergy and Infectious Diseases awarded the University of Missouri System $3,987,706 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate immune mechanisms shaping airborne influenza transmission through an integrated program combining swine and human studies with multiscale computational modeling. The research addresses the mechanistic gap in understanding how host immunity and environmental conditions govern...
- The National Institute of Allergy and Infectious Diseases awarded The Washington University $305,908 on December 23, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate mechanisms of sigma-factor-dependent transcriptional control in Mycobacterium tuberculosis. The research employs experimental and computational approaches to understand the role of an intrinsically disordered region (IDR) in the sigma-A factor, which directs RNA polymerase to genes across...
- The National Institute of Allergy and Infectious Diseases awarded the University of Virginia $713,396 on August 21, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on the molecular mechanisms of protective lung resident memory T cells. The project examines how lung tissue-resident memory CD8+ T cells provide broad-spectrum protection against influenza infection, including heterologous protection against variant strains. The research focuses on a...
- The National Institute of Allergy and Infectious Diseases awarded The Trustees of Columbia University in the City of New York $3,144,408 on February 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate regulatory T cell memory in human tissues. The award funds research to characterize the role, identity, and function of human regulatory T cells (Tregs) across diverse tissues and their interactions with immune and structural cells. The project will...
- The National Institute of Allergy and Infectious Diseases awarded The Curators of The University of Missouri, doing business as University of Missouri at Kansas City, $157,500 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to decode the glycan compositions and structures of two forms of glycosylated RNA (GlycoRNA-L and GlycoRNA-S) expressed in leukocytes. The research employs metabolic labeling combined with enzymatic digestion and purification of...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded $427,623 to The Washington University on February 24, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research dissecting how HIV-induced immunometabolic perturbation impairs tuberculosis control in people living with HIV despite effective antiretroviral therapy and viral suppression. The research...
- The National Institute of Allergy and Infectious Diseases, a division of the Department of Health and Human Services, awarded the University of Maryland, Baltimore $312,537 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 1, 2026, to support the Mechanisms Integrating Nervous and Immune Systems Training Program (MINISTP). The award funds a two-tiered training curriculum designed to prepare three graduate students and two post-doctoral researchers for up to...
- The National Institute of Allergy and Infectious Diseases awarded The University of Iowa $427,625 on February 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on how TRAF3 regulates CD4 T cell differentiation and function during chronic infections. The research employs single-cell technologies and cutting-edge genomic and epigenetic approaches—including single-cell RNA sequencing—to dissect how TRAF3 integrates T cell receptor, cytokine, and...
- The National Institute of Allergy and Infectious Diseases awarded the University of Missouri System $538,501 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and characterize RNA aptamer tools for studying HIV capsid protein structural dynamics and function. The award funds research to develop novel aptamers capable of discriminating among distinct structural forms of HIV's CA protein, which plays critical roles in viral assembly,...
- The National Institute of Allergy and Infectious Diseases awarded the University of Missouri System $805,253 on July 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate mechanisms underlying airborne transmission of seasonal influenza A viruses, specifically H1N1 and H3N2 subtypes. The recipient will characterize aerosol particle size distributions and virion morphologies of H1N1 and H3N2 using samples from human patients, laboratory-generated...
The National Institute of Allergy and Infectious Diseases awarded the University of Missouri System $2.767 million on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the NFKB signaling network in the regulation of resident T cell memory. The research addresses how tissue-resident memory T cells (TRM) are generated and maintained in the lungs following infection. While CD8 TRM cells in multiple tissues provide superior protection against pathogen re-infection compared to other T cell memory subsets, lung TRM cells rapidly decline after infection, leaving hosts unprotected. The work focuses on understanding how NFKB signaling—a complex pathway known for its role in inflammation—regulates TRM generation and maintenance in the context of inflammatory respiratory infections and local antigen and TGF-beta signals. The project employs two novel inducible models allowing T cell-intrinsic manipulation of NFKB levels to explore these interactions. Performance occurs in Columbia, Missouri. The award period runs from August 1, 2026, through July 31, 2030. This is a Project Grant, a standard assistance type under the NIAID program that funds biomedical research and research training in infectious diseases and related areas at public and nonprofit private institutions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.8m | 7/30/26 |