This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $243,750 to the University of Wisconsin - Madison to investigate how the bacteria Gardnerella promotes the pathogenesis of Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhea. The research aims to determine the mechanisms by which two Gardnerella virulence factors, vaginolysin and sialidase,...
This $174,767 Project Grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases will fund research into host defense mechanisms of resident peritoneal macrophages. Specifically, the awardee, Washington University, will examine how large peritoneal macrophages interact with mesothelial surfaces and promote clotting in the peritoneal cavity. This appears aimed at better understanding the immune response against infections and tumors in the peritoneum. The...
This federal Project Grant award, valued at $243,361.00 and running from August 15, 2024 to July 31, 2026, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant is funding a project by Rush University Medical Center in Chicago, Illinois to establish workflows for rapid and inexpensive whole genome sequencing (WGS) of Neisseria gonorrhoeae (NG) directly from urine, throat, and rectal...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $229,411 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Northwestern University to investigate Neisseria gonorrhoeae double-stranded bacteriophage. The research aims to determine whether one or more phage islands can produce phage, explore the regulation of two essential LexA orthologs, and assess whether these phage(s) can infect Neisseria strains or species. This project builds upon the...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $533,750.00 to the University of Florida to study the role of macrophages in the increased HIV risk associated with bacterial vaginosis (BV). The research aims to determine how a non-optimal vaginal microbiome affects the activation and "training" of macrophages towards an HIV-permissive phenotype. This will be...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to characterize HIV reservoirs in macrophages and investigate mechanisms by which these cells resist antibody-dependent cellular cytotoxicity (ADCC). The $243,713 award to the University of Massachusetts Medical School aims to: 1) determine how HIV accessory proteins Nef and Vpu differentially regulate NK cell...
This $393,750.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund a 5-year research project to explore the fundamental cellular mechanisms driving cellular senescence in macrophages. The key objectives of this research project are to gain a deeper understanding of the cellular and molecular mechanisms underlying senescent macrophage biology. This includes investigating the roles...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $116,271 to the Rector & Visitors of the University of Virginia to conduct research on how the bacterial pathogen Neisseria gonorrhoeae (which causes the sexually transmitted infection gonorrhea) overcomes nutritional immunity and iron limitation during infection. The key objectives of the research are to: 1) characterize how the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $299,999 to Planet Biotechnology Incorporated to develop a novel bispecific antibody for the prevention of gonorrhea. The project aims to engineer a fusion protein that combines elements of human antibodies with immune system components to broadly neutralize the causative bacteria, Neisseria gonorrhoeae, including...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $399,100 Project Grant under the Allergy and Infectious Diseases Research Program (CFDA 93.855) to the Board of Regents of the University of Nebraska's University of Nebraska Medical Center (UNMC) Division. This 2-year project will investigate how the pathogen Chlamydia trachomatis manipulates the host cell protein PICALM to facilitate its own replication and survival, while minimizing host cell stress. The research aims...