The National Institute of Allergy and Infectious Diseases awarded a $924,254 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Michigan State University. The goal of this 5-year research project is to advance the molecular-level understanding of a signal transduction system in the bacterium Brucella abortus that influences its ability to survive environmental stresses and colonize mammalian hosts. The proposed studies aim to: 1) Define the mechanism of stress signal detection by a multi-kinase sensory system, 2) Characterize how the EIPB gene contributes to cell envelope function, and 3) Determine the regulatory mechanism of the small RNAs GSRN1 and GSRN2 in Brucella infection biology. This research has the potential to inform new treatments for microbial infections by targeting the sensory histidine kinases, which are not present in mammals. The grant commences on June 1, 2024 and is scheduled for completion on April 30, 2029.
Generated 3/4/25, 6:28 AM