Project Grant R01AI177540

Award Date 1/17/25
Completion Date 12/31/29
Dollars Obligated $513K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Iowa, USA
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This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $512,581 to Iowa State University to examine the influence of prostaglandin E2 (PGE2) on cellular and humoral immunity in the mosquito, Anopheles gambiae. The key objectives of this 5-year research project are to:

  1. Investigate the cellular and transcriptional events following PGE2 activation using single-cell and phenomics-based methodologies.
  2. Elucidate the mechanisms of PGE2-mediated immune priming through tissue-specific gene silencing techniques.
  3. Assess the potential impact of PGE2 dysregulation on pathogen infection outcomes and mosquito fitness by targeting enzymes involved in PGE2 degradation.

The expected outcomes of this foundational research will provide critical insights into PGE2 signaling, immune cell dynamics, and regulation of mosquito immunity. The findings could translate into novel strategies for mosquito control to reduce the burden of mosquito-borne diseases.

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