Project Grant R01AG104805
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging awarded $1,283,632 to the University of California, Los Angeles on September 30, 2025, under the Aging Research program (CFDA 93.866) to conduct the TARDIS-AD Project, a comparative and cost-effectiveness study of personalized targeted multifactorial approaches to reducing disparities in Alzheimer's disease and related dementias. The research leverages causal mediation, machine learning, and simulation modeling to identify personalized intervention strategies that...
- The National Institute on Aging awarded the University of California Irvine $636,124 for Project Grant R01AG100345 on September 2, 2026, under the Aging Research program (CFDA 93.866). The award funds multi-omic characterization of molecular pathways driving vulnerability and resilience to Alzheimer's disease in the oldest-old population (age 90 and above). The research employs an integrative multi-omic approach including single-nucleus RNA and ATAC sequencing, spatial transcriptomics, and...
- The National Institute on Aging awarded the University of Southern California $149,190 on August 6, 2026, under the Aging Research program (CFDA 93.866) to investigate how early-stage Alzheimer's disease disrupts coordinated release dynamics between acetylcholine and norepinephrine in the cortex and how this discoordination impairs cognitive performance. The research characterizes the evolution of coordinated cortical acetylcholine and norepinephrine release activity in vivo in wildtype mice,...
- The University of California, Los Angeles received a $2.7 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 1, 2025, with completion scheduled for August 31, 2029. This research project will generate rigorous evidence comparing health outcomes for older patients with Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) who are discharged from hospitals to home-based care versus facility-based...
- The National Institute on Aging awarded the University of California, Davis $690,934 on March 1, 2026, under the Aging Research program (CFDA 93.866) to investigate subjective cognitive decline as an early risk indicator for Alzheimer's disease and related dementias across racially and ethnically diverse older adult populations. The research addresses a critical knowledge gap in existing literature, which has predominantly focused on White older adults. The project examines how subjective...
- The National Institute on Aging awarded the University of California, Berkeley $549,260 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop advanced large language model-based AI tools that enhance precision in predicting Alzheimer's disease pathology and cognitive outcomes. The research addresses critical gaps in precision medicine for Alzheimer's disease, particularly the need to capture patient heterogeneity, accurately identify treatment candidates for...
- The National Institute on Aging awarded Education Development Center, Inc. $320,150 under the Aging Research program (CFDA 93.866) on September 1, 2026. The research project examines elder mistreatment and self-neglect among older adults with Alzheimer's disease and related dementias, leveraging the UCLA Alzheimer's and Dementia Care (ADC) Program's longitudinal dataset of structured data and clinical notes from dementia care specialists. The study expands the existing dataset to include three...
- The National Institute on Aging awarded The University of Chicago $597,239 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support investigation of inpatient rehabilitation facility (IRF) utilization and outcomes for older adult patients with and without Alzheimer's disease or other dementias (ADRD). The research examines comparative value and appropriateness of care delivery across post-acute care settings, specifically comparing higher-cost IRF care—which provides acute...
- The National Institute on Aging awarded the University of California, Los Angeles $126,063 on August 5, 2026, under the Aging Research program (CFDA 93.866) to determine the atomic structures of amyloid-beta and tau oligomers and to characterize the molecular interaction between amyloid-beta and the TREM2 receptor on microglia. The award is classified as a Project Grant, specifically a K99/R00 award. The research develops a novel oligomer structure determination pipeline incorporating native...
The National Institute on Aging awarded the University of California, Los Angeles $623,176 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on modifiable risk factors for Alzheimer's disease and related dementias among individuals aged 90 and older. The research triangulates evidence across four data sources—the LifeAfter90 Study (1,397 participants, all aged 90), the 90+ Study (1,630 participants, all aged 90), the Health and Retirement Study (3,359 participants aged 90 of 45,234 total), and the National Health and Aging Trends Study (3,132 participants aged 90 of 18,439 total)—to identify and validate social, behavioral, and clinical determinants of cognitive decline in the oldest-old population. The project applies quantitative bias analysis and rigorous statistical methods to correct biases inherent in individual data sources and to deliver valid estimates in settings where conventional epidemiological methods may fail. Research focuses on factors that are modifiable and particularly relevant to preventing AD/ADRD in this age group. Work is performed in Los Angeles, California, with a period of performance from September 1, 2026, through April 30, 2031. The assistance type is Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $623.2k | 8/26/26 |