Project Grant R01AG098476
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital $6.76 million under the Aging Research program (CFDA 93.866) for a four-year project period (September 1, 2025 – August 31, 2029) to conduct clinical research on emotional distress in young onset dementia (YOD) populations. The primary deliverable is a single-blind, randomized controlled trial (RCT) comparing the efficacy and durability of Resilient Together-YOD (RT-YOD), a dyadic...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital $459,250 under the Aging Research program (CFDA 93.866) on June 1, 2025, for a two-year project extending through May 31, 2027. This project grant supports longitudinal research investigating the mechanisms by which stress and resilience influence cognitive aging and Alzheimer's disease (AD) progression. The research will analyze existing data from two natural history,...
- Federal Grant Award Summary Massachusetts General Hospital (The General Hospital Corporation) received a $3.17 million Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective February 15, 2026 through February 14, 2030. The award funds development and evaluation of cell therapy approaches to treat Alzheimer's disease by restoring inhibitory neural circuit function. The research focuses on transplanting embryonic mouse medial ganglionic...
- Federal Grant Award Summary The National Institute on Aging awarded a $684,567 Project Grant to Massachusetts General Hospital (The General Hospital Corporation) for a four-year research initiative beginning March 1, 2026 and concluding December 31, 2029, under the Aging Research program (CFDA 93.866). The grant supports a resubmission methodology study designed to assess the utility of 64Copper-Fibrin-Binding-Probe-8 Positron Emission Tomography (64Cu-FBP8 PET) for in vivo detection and...
- Summary of Federal Project Grant Award The National Institute on Aging awarded $129,330 in Project Grant funding to Massachusetts General Hospital (The General Hospital Corporation) under the Aging Research program (CFDA 93.866) for the period June 15, 2025 through March 31, 2030. This award supports research addressing the critical challenge of early detection and accurate diagnosis of Alzheimer's Disease and Related Dementias (ADRD) through development of a machine learning-based prediction...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Massachusetts General Hospital a Project Grant of $234,630 on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This five-year award, extending through July 31, 2030, supports research to evaluate low-intensity focused ultrasound pulsation (LIFUP) as a therapeutic intervention for patients with disorders of...
- Federal Project Grant Award Summary Massachusetts General Hospital received $825,000 in project grant funding from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded on September 15, 2025, with a completion date of August 31, 2027. This project grant supports research exploring serious illness communication (SIC) between Latino Spanish-speaking older adults and community-based palliative care clinicians in clinic and home-based settings. The research...
- Federal Project Grant Award Summary The National Institute on Aging awarded Massachusetts General Hospital a $487,574 Project Grant on May 15, 2025, under the Aging Research program (CFDA 93.866) to conduct biomedical research investigating the role of reactive astrocytes in the propagation and clearance of tau pathology in Alzheimer's disease. The project, with a completion date of February 28, 2030, will deliver scientific research outputs aimed at understanding whether glial fibrillary acidic...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital a $1.58 million Project Grant on March 15, 2025, under the Aging Research program (CFDA 93.866) to conduct research characterizing microvascular impairment in adults with elevated genetic risk for Alzheimer's disease. The research initiative, which extends through January 31, 2030, investigates the physiological mechanisms through which the apolipoprotein E-epsilon 4 (APOE-E4) allele—the...
- Federal Project Grant Award Summary Beth Israel Deaconess Medical Center, Inc. (BIDMC) received a $107,330 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective August 15, 2025, with completion targeted for April 30, 2027. This award supports the development of a scalable model to estimate treatment burden in older adults with multiple chronic conditions (MCCs) by leveraging nationally representative data from the 2022 Health and...
Massachusetts General Hospital received a $722,746 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective February 15, 2026, through January 31, 2031, to conduct a multi-site clinical trial testing the efficacy of the COMA Family Program (COMA-F). COMA-F is a resilience intervention designed to address emotional distress in caregivers of patients with severe acute brain injury (SABI) who are treated in intensive care units. The program delivers six weekly video-based sessions of 30-45 minutes each, teaching caregivers evidence-based coping skills and mindfulness techniques to manage stressors associated with acute and long-term caregiving responsibilities. The intervention addresses a significant clinical gap, as approximately 50% of caregivers for SABI patients experience chronic emotional distress, yet this population has historically been excluded from clinical trials and lacks access to evidence-based psychosocial treatment. COMA-F was developed following the National Institutes of Health Stage Model, building upon an efficacious prior intervention and incorporating feedback from 30 SABI caregivers across 14 neuro-intensive care units. The remote delivery format and low-burden session structure increase accessibility and accommodate caregivers' competing time demands and feelings of overwhelm during the critical early period following patient admission, with the aim of preventing development of chronic distress.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 2/9/26 | ||
| Not listed | $722.7k | 2/3/26 |