Project Grant R01AG098139
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $1.25 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) to develop an integrated artificial intelligence (AI)-driven computational and experimental workflow for accelerating small-molecule drug discovery targeting Alzheimer's disease. The award, effective February 15, 2026 through January 31, 2031, supports research aimed at identifying chemical probes...
- Federal Grant Award Summary Alphamemory, LLC received a Phase I Small Business Technology Transfer (STTR) award of $504,248 from the National Institute on Aging under the Aging Research program (CFDA 93.866) to develop novel drug candidates targeting Alzheimer's disease (AD). The project, which commenced on September 20, 2025, and extends through September 19, 2027, aims to create therapeutics that selectively reduce amyloid production through an alternative mechanism to previous failed...
- Federal Project Grant Award Summary Advantage Therapeutics, Inc. received a $1.25 million Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 20, 2025, with completion anticipated by May 31, 2027. The award supports preclinical and Investigational New Drug (IND)-enabling studies for a small-molecule, disease-modifying therapeutic candidate for Alzheimer's disease. The compound is designed to function as an...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Scripps Research Institute a $506,000 project grant under the Aging Research program (CFDA 93.866) beginning August 15, 2025, with completion scheduled for July 31, 2027. The award funds research focused on engineering synthetic biomolecular condensates (BMCs) to enable targeted autophagy modulation, a promising therapeutic target for age-related diseases. The primary deliverable is development of an advanced...
- Federal Grant Award Summary J. David Gladstone Institutes received a Project Grant award of $817,357 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 15, 2025, with a completion date of March 31, 2030. The award supports research applying novel machine learning (ML) approaches to behavioral analysis and brain signal integration in humanized Alzheimer's disease (AD) models. The primary deliverable involves validation and development of a...
- Federal Project Grant Award Summary Aivocode, Inc. received a $1.24M Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) to develop single domain antibodies targeting Connective Tissue Growth Factor (CTGF) as a therapeutic intervention for vascular dysfunction in Alzheimer's disease. The award, issued September 20, 2025, with completion targeted for May 31, 2027, funds Phase II research to test antibody candidates in transgenic mouse models...
- Federal Grant Award Summary The University of South Florida received a $3.3 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 1, 2025 through August 31, 2029. This award supports the development of novel peptidomimetic biomaterials designed to inhibit amyloid-beta (Aβ42) aggregation as a therapeutic intervention for Alzheimer's disease. The primary deliverables include the rational design and synthesis of structurally...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Indiana University a $1.23 million Project Grant under the Aging Research program (CFDA 93.866) to develop artificial intelligence-driven virtual screening pipelines for identifying brain-penetrant drug candidates targeting Alzheimer's disease and related dementias (AD/ADRD). The five-year project, running from February 1, 2026, through January 31, 2031, will deliver computational tools and datasets designed to...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $6.67 million to the University of Illinois under the Aging Research program (CFDA 93.866) for a four-year project (September 1, 2025 – August 31, 2029) to develop small molecule ligands targeting pathological tau signaling in Alzheimer's disease and related dementias. The research addresses a critical unmet need by identifying compounds that block the tau phosphatase activating domain (PAD), preventing the...
- Federal Project Grant Award Summary Duke University's Office of Research Administration was awarded $509,413 by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) on September 15, 2025, for a project period extending through May 31, 2030. The award supports scientific research investigating epitranscriptomic regulation of microglia in Alzheimer's disease (AD), specifically examining how m6A (N6-methyladenosine) modifications of messenger RNA control microglial...
Fox Chase Chemical Diversity Center Inc. received a $1.07 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective March 1, 2026 through November 30, 2030. The award supports AI-driven discovery of in vivo chemical probes targeting understudied proteins relevant to Alzheimer's disease and related dementias (ADRD). The project will systematically evaluate 15 proteins annually from the 900-protein portfolio maintained by the TREAT-AD (Target Enablement to Accelerate Therapy Development for Alzheimer's Disease) Center, with five targets advanced annually through structure-activity relationship (SAR) development activities to generate novel chemical probes distributed publicly via the TREAT-AD platform. The project encompasses five integrated objectives: target selection aligned with TREAT-AD priorities; virtual screening of compound libraries for novel binding activity; assay development and testing of lead candidates; machine learning algorithm development for lead optimization; and medicinal chemistry refinement coupled with biochemical and functional characterization including absorption, distribution, metabolism, and excretion (ADME) profiling. This work directly supports the National Institute on Aging's priorities in accelerating therapeutic development for age-related neurodegenerative diseases through application of artificial intelligence and machine learning methodologies to drug discovery, while leveraging Fox Chase Chemical Diversity Center's established expertise in virtual screening workflows and medicinal chemistry.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.1m | 2/17/26 |