Project Grant R01AG095819
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $848,286 to the University of South Florida to conduct research on the role of N6-methyladenosine (m6A) RNA modifications in Alzheimer's disease (AD). The key objectives are to: 1) Create a high-resolution map of m6A sites in the brains of older adults, 2) Identify specific m6A alterations associated with AD and its clinical/pathological features, and 3) Elucidate how m6A dysregulation may...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $805,573 project grant to The Regents of the University of California, San Francisco to investigate the impact of m6A RNA modifications in Alzheimer's disease and related tauopathies. The grant will support research to uncover changes in m6A RNA modifications and their functional consequences in post-mortem brain tissue from subjects with Alzheimer's disease and other tauopathies,...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
- This $6,925,230 Project Grant award from the National Institutes of Health (NIH) National Institute on Aging (CFDA 93.866 - Aging Research) will support a research project at The Trustees of Columbia University in the City of New York to develop a "Multi-Organ Chart of Personalized Susceptibility to Alzheimer's Disease and Aging." The overarching goal is to use large-scale multi-omics, multi-organ biomedical data, advanced artificial intelligence/machine learning, and computational...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to elucidate the role of RNA modification, specifically N6-methyladenosine (m6A), in the pathogenesis of Alzheimer's disease (AD) and related tauopathies. The total award amount is $745,092 over the project period from January 1, 2025 to November 30, 2029. The key objectives are to: 1) decode the epitranscriptomic profiles impacted by tau pathology using m6A DART-seq; 2) determine the role of RNA...
- The federal Project Grant award of $3,642,232.00, awarded on August 5, 2025 by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to leverage genetics and multi-omic data to identify causal genes, cell types, and molecular mechanisms underlying Alzheimer's disease (AD). The project, titled "UNRAVELING THE GENETIC BASIS OF MOLECULAR FUNCTIONS IN ALZHEIMER'S DISEASE", will integrate multi-ancestry molecular quantitative trait loci (xQTL) data...
- This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,041,438 to develop new computational tools and biomarkers for Alzheimer's disease. The University of Miami will aggregate and analyze DNA methylation datasets to identify age-associated epigenetic changes related to aging and Alzheimer's progression. Researchers will create a searchable web interface to disseminate findings on the role of DNA...
- This Project Grant award titled "Epitranscriptomic Regulation of Microglia in Alzheimer's Disease" was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to Duke University. The $509,413 grant, awarded on September 15, 2025, will support research to understand the role of epitranscriptomic regulation, specifically the m6A modification, in controlling microglial function and its contribution to Alzheimer's disease pathogenesis. The project aims to elucidate how...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), has awarded a $595,769 project grant to The University of Kentucky Research Foundation. The grant, effective from September 15, 2025 to August 31, 2030, will support research to investigate the role of RNA modifications on the translation of circular RNAs in Alzheimer's disease (AD). The project aims to determine the mechanism of inosine-mediated translation of AD-relevant circular RNAs, assess...
- This $342,934.65 project grant from the Department of Health and Human Services National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into acyl chain remodeling and regional lipid dysregulation in Alzheimer's disease. The Trustees of Columbia University in the City of New York, doing business as Health Sciences Division, will analyze lipid composition in brain regions susceptible to Alzheimer's disease, such as the...
The National Institute on Aging (NIA), under the Department of Health and Human Services, awarded a $852,273 Project Grant titled "Genetic Mapping of M6A and Pseudouridine RNA Modifications in the Aging Human Brain and Their Impact on Alzheimer's Disease" to The Trustees of Columbia University in the City of New York. The project, which runs from September 1, 2025 to May 31, 2030, aims to investigate the role of RNA modifications in Alzheimer's disease through an innovative integration of genetics, multi-omics analysis, and functional validation. The key objectives are to: 1) create a comprehensive atlas of N6-methyladenosine (M6A) and pseudouridine (Ps) modifications in human brain cells, 2) integrate the genetic regulators of these modifications with Alzheimer's disease genome-wide association study data to elucidate their molecular functions and impact, and 3) characterize the molecular and cellular phenotypes of candidate M6A sites and Alzheimer's disease risk genes using human induced pluripotent stem cell models. This project seeks to identify novel therapeutic targets with clear genetic underpinnings, potentially leading to the discovery of new Alzheimer's disease biomarkers and treatment strategies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $131.2k | 9/9/25 | ||
| Not listed | $721.1k | 8/28/25 |