Project Grant R01AG095417
- Federal Project Grant Award Summary The University of Michigan's Regents received a $442,695 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded May 1, 2025, with completion targeted for January 31, 2027. This proof-of-concept research initiative aims to develop immunocytokines—monoclonal antibodies (MAbs) or bispecific antibodies (BAbsbs) fused to macrophage colony-stimulating factor (M-CSF)—to achieve selective, sustained, and localized...
- SUMMARY The National Institute on Aging awarded a $284,108 Project Grant to the Regents of the University of Michigan for the period January 1, 2026 through December 31, 2027, under the Aging Research program (CFDA 93.866). The research project will deliver scientific investigation into the impact of age-related mechanical changes in the brain on microglial activity and implications for Alzheimer's disease (AD) progression. The deliverables include development of a three-dimensional in vitro...
- Federal Grant Award Summary The University of Michigan received a $10.4 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded on August 1, 2025, with completion scheduled for July 31, 2029. This research initiative represents the first study evaluating personalized brain stimulation as a treatment for Posterior Cortical Atrophy (PCA), a neurodegenerative condition most commonly caused by Alzheimer's disease. The primary deliverable...
- Federal Project Grant Award Summary The University of Michigan's Regents received a $2,991,725 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025, through August 31, 2029. This award supports fundamental biomedical research investigating how reactive oxygen species (ROS) and early-in-life oxidative stress modulate lifespan and aging processes. The research employs a multipronged approach utilizing model...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Michigan a $303,449 project grant effective June 1, 2025, through May 31, 2027, under the Aging Research program (CFDA 93.866) to investigate the genomic impact of transposable elements (TEs) in Alzheimer's disease and related dementias (ADRD). The research will leverage large-scale genomic datasets and clinical information from major Alzheimer's disease cohorts to overcome analytical challenges...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Michigan's Regents a $298,419 Project Grant effective February 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This award supports the development of novel machine learning and computational statistical methods designed to analyze immune system data and advance understanding of immunosenescence and aging-related diseases. The research addresses critical...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $3.06 million Project Grant under the Aging Research program (CFDA 93.866) to Henry Ford Health + Michigan State University Health Sciences for a 48-month research initiative beginning September 15, 2025. This project aims to optimize and validate detection of microvessels within the cerebral vascular, glymphatic, and meningeal lymphatic systems using superparamagnetic iron oxide (SPIO)-enhanced susceptibility weighted...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Michigan $1,402,051 on August 1, 2025, under the Aging Research program (CFDA 93.866) to develop advanced machine learning methodologies for identifying factors associated with cognitive resilience in Alzheimer's disease and related dementias. The project, extending through April 30, 2030, involves the development of novel multimodal variational autoencoder (VAE) models designed to analyze...
- Federal Grant Award Summary The University of Michigan's Regents, Office of Research and Sponsored Projects, received a $1.73 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct comprehensive research on genetic determinants of cognitive outcomes under caloric restriction. The award, obligated on March 1, 2026, with completion anticipated by January 31, 2031, supports the first systems genetics analysis using the Diversity...
- Federal Project Grant Award Summary Duke University's Office of Research Administration was awarded $509,413 by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) on September 15, 2025, for a project period extending through May 31, 2030. The award supports scientific research investigating epitranscriptomic regulation of microglia in Alzheimer's disease (AD), specifically examining how m6A (N6-methyladenosine) modifications of messenger RNA control microglial...
Federal Project Grant Summary The University of Michigan, through its Office of Research and Sponsored Projects, received a $655,198 project grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective March 1, 2026, through November 30, 2030. This award supports research focused on developing non-invasive methods for modulating microglia gene expression through peripherally administered antibody conjugates. The project addresses a significant gap in current neuroscience research by leveraging bispecific antibodies (BAbs) that target transferrin receptor 1 (TFR-1) or CD98HC to facilitate delivery of antisense oligonucleotides (ASOs) across the blood-brain barrier (BBB) and into the brain parenchyma following intravenous administration. This approach offers advantages over conventional viral vectors, including reversibility, reduced toxicity and immunogenicity, and improved selectivity for microglia cell populations. The deliverables under this grant include proof-of-concept studies demonstrating selective in vivo gene silencing in microglia using peripherally administered CD11B BAb-ASOs. The research aims to establish a foundational technology platform with wide-reaching implications for understanding microglia physiology and developing targeted therapeutics for age-related neurological diseases. This work aligns directly with the National Institute on Aging's mission to support research addressing aging processes and age-related conditions, particularly neurodegenerative diseases including Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $655.2k | 2/16/26 |