Project Grant R01AG092773
- Federal Project Grant Award Summary The National Institute on Aging awarded the University of Oklahoma Health Sciences Center a $286,000 Project Grant (CFDA 93.866 – Aging Research) effective September 15, 2025, with completion targeted for August 31, 2027. This pilot study delivers novel biomedical research investigating the mechanisms by which age-related lipid dysregulation in brain vascular endothelial cells contributes to cognitive impairment. The research employs single-cell RNA-sequencing...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the Board of Regents of the University of Nebraska, operating through its University of Nebraska Medical Center (UNMC) division, a Project Grant of $3.24 million under the Aging Research program (CFDA 93.866). The award, effective September 15, 2025, through September 14, 2029, funds a longitudinal research study examining the influence of interpersonal connectedness between persons with dementia (PWD) and their spousal...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received $1,469,914 in project grant funding from the National Institute on Aging under the Aging Research program (CFDA 93.866) for the period January 1, 2026 through December 31, 2030. The award supports research titled "Probing Mechanistic Links Between Endothelial Aging and Dementia," which develops and applies a novel human induced pluripotent stem cell-endothelial cell (hiPSC-EC) model to investigate the...
- Federal Project Grant Award Summary Duke University's Office of Research Administration is executing a scientific research project funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The $715,801 project grant, awarded June 1, 2025, with completion scheduled for March 31, 2030, supports biomedical research investigating the mechanisms linking hypertension and aging to postoperative delirium and subsequent Alzheimer's disease and related dementias...
- Federal Project Grant Award Summary The University of Missouri System received a $429,394 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded December 15, 2025, with completion targeted for November 30, 2027. This research initiative addresses heart failure with preserved ejection fraction (HFpEF) in aging populations with comorbid conditions such as obesity and hypertension. The project focuses on investigating LARP6 (LA...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Johns Hopkins University a $480,710 Project Grant effective September 5, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). The award supports scientific investigation into a novel vascular signaling pathway that regulates neuronal survival in neurodegenerative diseases, specifically Alzheimer's disease and related dementias (ADRD), amyotrophic lateral sclerosis (ALS), and...
- Federal Project Grant Award Summary The University of Nebraska Medical Center (UNMC) received a $435,372 Project Grant award dated August 13, 2025, from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant supports the development and advancement of a novel electrotaxis system designed to enhance chronic wound healing. The research addresses a...
- Federal Project Grant Award Summary Funding Agency: National Institute on Aging Federal Grant Program: Aging Research (CFDA 93.866) Award Date: September 15, 2025 Completion Date: August 31, 2026 Total Funding Obligated: $499,943.00 Aster Labs, Inc., a minority-owned small business located in Shoreview, Minnesota, will design and develop a novel, unobtrusive wearable device for continuous gait monitoring in older Black adults with Alzheimer's disease and related dementias (ADRD). The device will...
- Federal Project Grant Award Summary The University of Nebraska, through its Board of Regents, received a $198,263 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), awarded on September 5, 2025, with completion scheduled for August 31, 2027. This research project investigates the role of mitsugumin 53 (MG53), a protein identified in hibernating mammals, in...
- Federal Grant Award Summary Northeast Ohio Medical University received a $611,680 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective February 1, 2026 through January 31, 2031. The award supports biomedical research investigating the molecular mechanisms by which metabolic syndrome accelerates vascular aging. The research focuses on O-GlcNAcylation—a post-translational protein modification—and its role in vascular smooth muscle...
The University of Nebraska Medical Center (UNMC) received a $644,298 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with a completion date of January 31, 2031. The grant supports research and development of next-generation treatments for peripheral artery disease (PAD), a progressive vascular condition affecting the lower extremities. The primary deliverable is comparative preclinical evaluation of regenerative, cell-based therapeutic regimens—specifically autologous adipose stromal vascular fraction (SVF) and SVF-derived exosomes—using a clinically relevant porcine hindlimb ischemia model. UNMC will conduct research to optimize cell delivery strategies targeting collateral vessel inflow at the aortic trifurcation, with the objective of demonstrating enhanced arteriogenesis and improved hemodynamic and functional outcomes compared to standard treatment approaches. This project directly supports the National Institute on Aging's mission to advance biomedical research addressing age-related diseases and conditions affecting older adults. The research outcomes are intended to provide preclinical evidence supporting the development of improved regenerative therapies that could reduce patient reliance on costly interventional procedures while enhancing limb perfusion and functional capacity in PAD patients. The five-year project period allows for comprehensive comparative analysis and validation of these novel cell-based therapeutic approaches.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | ($43k) | 1/28/26 | ||
| Not listed | $687.1k | 1/22/26 |